Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are involved in both host defense and regulation of intestinal inflammation. However, factors that regulate their functions are poorly understood. In this study, we find that the gut microbiota represses IL-17 production...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-07, Vol.36 (1), p.2128-2129, Article 109332
Hauptverfasser:	Dupraz, Louise, Magniez, Aurélie, Rolhion, Nathalie, Richard, Mathias L., Da Costa, Grégory, Touch, Sothea, Mayeur, Camille, Planchais, Julien, Agus, Allison, Danne, Camille, Michaudel, Chloé, Spatz, Madeleine, Trottein, François, Langella, Philippe, Sokol, Harry, Michel, Marie-Laure
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cecum - cytology Cellular Biology Fatty Acids, Volatile - pharmacology Female Gastrointestinal Microbiome - drug effects Gastrointestinal Tract - drug effects Gastrointestinal Tract - microbiology gut Histone Deacetylase Inhibitors - pharmacology Humans IL-17 Immunology Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Interleukin-17 - biosynthesis Interleukin-22 Interleukins - biosynthesis Intestines - cytology Life Sciences Life Sciences & Biomedicine Male Mice Mice, Inbred C57BL Middle Aged propionate Receptors, Antigen, T-Cell, gamma-delta - metabolism SCFA Science & Technology Surgery T cells Transplantation Vancomycin - pharmacology
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