Vasodilatory effect of pentoxifylline in isolated equine digital veins

The direct vasodilatory action of pentoxifylline (1-(5-oxohexyl)-3,7-dimethylxanthine) and its signalling pathway was evaluated in equine digital veins. Cumulative concentration–response curves to pentoxifylline (1nM to 300μM) were recorded in phenylephrine-precontracted equine digital vein rings un...

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Veröffentlicht in:	The veterinary journal (1997) 2012-06, Vol.192 (3), p.368-373
Hauptverfasser:	Kabbesh, N., Gogny, M., Chatagnon, G., Noireaud, J., Thorin, C., Desfontis, J.-C., Mallem, M.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists cGMP-dependent protein kinase Colforsin - pharmacology cyclic AMP cyclic GMP Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Dose-Response Relationship, Drug Endothelium Endothelium, Vascular - physiology Equine digital veins forskolin guanosine monophosphate guanylate cyclase horses Horses - physiology indomethacin Indomethacin - pharmacology Life Sciences Nitric oxide nitric oxide synthase nitroprusside Nitroprusside - pharmacology Pentoxifylline Pentoxifylline - pharmacology prostaglandin synthase signal transduction Tissue Culture Techniques Vasodilation Vasodilation - drug effects Vasodilator Agents - pharmacology Veins - drug effects
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