Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder

Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loc...

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Veröffentlicht in:	Molecular psychiatry 2021-09, Vol.26 (9), p.5229-5238
Hauptverfasser:	Fears, Scott C., Service, Susan K., Kremeyer, Barbara, Araya, Carmen, Araya, Xinia, Bejarano, Julio, Ramirez, Margarita, Castrillón, Gabriel, Gomez-Franco, Juliana, Lopez, Maria C., Montoya, Gabriel, Montoya, Patricia, Aldana, Ileana, Teshiba, Terri M., Al-Sharif, Noor B., Jalbrzikowski, Maria, Tishler, Todd A., Escobar, Javier, Ruiz-Linares, Andrés, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Reus, Victor I., Cantor, Rita M., Sabatti, Chiara, Freimer, Nelson B., Bearden, Carrie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 59/57 631/208 631/378 Association analysis Behavioral Sciences Biological anthropology Biological Psychology Bipolar disorder Bipolar Disorder - genetics Brain Brain - diagnostic imaging Brain mapping Brain research Chromosome 1 Chromosome 7 Corpus callosum Development and progression Gene mapping Genetic aspects Genetic Linkage - genetics Genomes Health aspects Humanities and Social Sciences Humans Linkage analysis Medicine Medicine & Public Health Neurosciences Pedigree Pharmacotherapy Phenotype Phenotypes Phenotypic variations Population genetics Psychiatry Psychological aspects Quantitative trait loci Quantitative Trait Loci - genetics Risk factors Single-nucleotide polymorphism Structure
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