Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study
Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting resul...
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| Veröffentlicht in: | Brain imaging and behavior 2021-06, Vol.15 (3), p.1499-1507 |
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| creator | Siragusa, Marta Andrea Rufin, Thomas Courtois, Robert Belzung, Catherine Andersson, Frédéric Brizard, Bruno Dujardin, Paul-Armand Cottier, Jean-Philippe Patat, Frédéric Réméniéras, Jean-Pierre Gissot, Valérie El-Hage, Wissam Camus, Vincent Desmidt, Thomas |
| description | Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (
n
= 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression. |
| doi_str_mv | 10.1007/s11682-020-00348-w |
| format | Article |
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= 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-020-00348-w</identifier><identifier>PMID: 32761564</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amygdala ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Blood flow ; Body mass index ; Body size ; Brain ; Cerebral blood flow ; Cerebrovascular diseases ; Human health and pathology ; Humanities and Social Sciences ; Life Sciences ; Magnetic resonance imaging ; Medical imaging ; Neuroimaging ; Neuropsychology ; Neuroradiology ; Neurosciences ; Neurosis ; Original Research ; Psychiatrics and mental health ; Psychiatry ; Psychology ; Risk analysis ; Risk factors ; Ultrasonic imaging ; Ultrasonic testing ; Ultrasound</subject><ispartof>Brain imaging and behavior, 2021-06, Vol.15 (3), p.1499-1507</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-27b130c14ea7f59e51eb511a9a27f7f6982ecc81c960e8a0f897a7fb9b6692373</citedby><cites>FETCH-LOGICAL-c430t-27b130c14ea7f59e51eb511a9a27f7f6982ecc81c960e8a0f897a7fb9b6692373</cites><orcidid>0000-0001-8933-7205 ; 0000-0002-6845-221X ; 0000-0001-6095-5974 ; 0000-0002-3557-5264 ; 0000-0003-3877-0855 ; 0000-0002-2343-2450 ; 0000-0002-0110-822X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-020-00348-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-020-00348-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03265218$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Siragusa, Marta Andrea</creatorcontrib><creatorcontrib>Rufin, Thomas</creatorcontrib><creatorcontrib>Courtois, Robert</creatorcontrib><creatorcontrib>Belzung, Catherine</creatorcontrib><creatorcontrib>Andersson, Frédéric</creatorcontrib><creatorcontrib>Brizard, Bruno</creatorcontrib><creatorcontrib>Dujardin, Paul-Armand</creatorcontrib><creatorcontrib>Cottier, Jean-Philippe</creatorcontrib><creatorcontrib>Patat, Frédéric</creatorcontrib><creatorcontrib>Réméniéras, Jean-Pierre</creatorcontrib><creatorcontrib>Gissot, Valérie</creatorcontrib><creatorcontrib>El-Hage, Wissam</creatorcontrib><creatorcontrib>Camus, Vincent</creatorcontrib><creatorcontrib>Desmidt, Thomas</creatorcontrib><title>Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><description>Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (
n
= 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.</description><subject>Amygdala</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood flow</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Brain</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular diseases</subject><subject>Human health and pathology</subject><subject>Humanities and Social Sciences</subject><subject>Life Sciences</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Neuroimaging</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosis</subject><subject>Original Research</subject><subject>Psychiatrics and mental 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study</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>15</volume><issue>3</issue><spage>1499</spage><epage>1507</epage><pages>1499-1507</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (
n
= 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32761564</pmid><doi>10.1007/s11682-020-00348-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8933-7205</orcidid><orcidid>https://orcid.org/0000-0002-6845-221X</orcidid><orcidid>https://orcid.org/0000-0001-6095-5974</orcidid><orcidid>https://orcid.org/0000-0002-3557-5264</orcidid><orcidid>https://orcid.org/0000-0003-3877-0855</orcidid><orcidid>https://orcid.org/0000-0002-2343-2450</orcidid><orcidid>https://orcid.org/0000-0002-0110-822X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala Biomarkers Biomedical and Life Sciences Biomedicine Blood flow Body mass index Body size Brain Cerebral blood flow Cerebrovascular diseases Human health and pathology Humanities and Social Sciences Life Sciences Magnetic resonance imaging Medical imaging Neuroimaging Neuropsychology Neuroradiology Neurosciences Neurosis Original Research Psychiatrics and mental health Psychiatry Psychology Risk analysis Risk factors Ultrasonic imaging Ultrasonic testing Ultrasound |
| title | Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study |
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