Freeze-Frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation

The 1,3-dipolar cycloaddition reaction between unactivated azides and acetylenes proceeds exceedingly slowly at room temperature. However, considerable rate acceleration is observed when this reaction occurs inside the active center gorge of acetylcholinesterase (AChE) between certain azide and acet...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (6), p.1449-1454
Hauptverfasser:	Bourne, Yves, Kolb, Hartmuth C., Radić, Zoran, Sharpless, K. Barry, Taylor, Palmer, Marchot, Pascale
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Acetylcholinesterase - drug effects Atoms Biochemistry Biological Sciences Canyons Catalysis Cell Line Cholinesterase Inhibitors - pharmacology Crystallization Cycloaddition Enzymes Humans Indoles Isomerism Isomers Kinetics Life Sciences Ligands Pain Proteins Reactants Temperature Triazoles
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!