Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly

The crystal structure of mouse acetylcholinesterase at 2.9-A resolution reveals a tetrameric assembly of subunits with an antiparallel alignment of two canonical homodimers assembled through four-helix bundles. In the tetramer, a short Omega loop, composed of a cluster of hydrophobic residues conser...

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Veröffentlicht in:	The Journal of biological chemistry 1999-01, Vol.274 (5), p.2963-2970
Hauptverfasser:	Bourne, Y, Taylor, P, Bougis, P E, Marchot, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Amino Acid Sequence Animals Crystallography, X-Ray Helix-Loop-Helix Motifs Life Sciences Mice Models, Molecular Molecular Sequence Data Protein Conformation
Online-Zugang:	Volltext
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