Homologues of a K + channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration

Three polypeptides (β, γ and δ) homologous to α-dendrotoxin, an inhibitor of certain voltage-activated K + channels, were found to elevate the cytosolic free concentration of calcium ([Ca 2+] c) in isolated central nerve terminals. Relative to α-dendrotoxin (EC 50 − 2.1 nM), the β-, γ- and δ-toxins...

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Veröffentlicht in:	Neurochemistry international 1990, Vol.16 (1), p.105-112
Hauptverfasser:	Muniz, Z.M., Tibbs, G.R., Maschot, P., Bougis, P., Nicholls, D.G., Dolly, J.O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Biological and medical sciences Life Sciences Medical sciences Toxicology
Online-Zugang:	Volltext
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