Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

Currently in vivo gene delivery by synthetic vectors is hindered by the limited diffusibility of complexes in extra-cellular fluids and matrices. Here we show that certain formulations of plasmid DNA with linear polyethylenimine (22 kDa PEI, ExGene 500) can produce complexes that are sufficiently sm...

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Veröffentlicht in:	Gene therapy 1998-05, Vol.5 (5), p.712-717
Hauptverfasser:	GOULA, D, REMY, J. S, ERBACHER, P, WASOWICZ, M, LEVI, G, ABDALLAH, B, DEMENEIX, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Biological and medical sciences Biotechnology Brain - metabolism Central nervous system Cerebrospinal fluid Cytomegalovirus - genetics Deoxyribonucleic acid DNA DNA, Circular - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene transfer Gene Transfer Techniques Genes, Reporter Genetic Vectors Health. Pharmaceutical industry Immunocytochemistry Immunohistochemistry Industrial applications and implications. Economical aspects Injection Lac Operon - genetics Life Sciences Mice Microscopy, Fluorescence Neuronal-glial interactions Other Physiology Plasmids Polyethyleneimine - pharmacology Transfection Transfection - drug effects Ventricle β-Galactosidase
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