Paradoxical effects of ethoxidine, a topoisomerase I inhibitor, in the cellular processes leading to angiogenesis on endothelial cells

Angiogenesis, a critical step in tumorigenesis, is defined by different processes leading to neovascularization. Topoisomerase I (Top I) is the target for some of the most successful anticancer drugs that decrease tumor cell proliferation. Ethoxidine, a benzo[c]phenanthridines derivative, camptothec...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-03, Vol.32 (3), p.286-295
Hauptverfasser:	CLERE, Nicolas, FAURE, Sébastien, HELESBEUX, Jean-Jacques, DUVAL, Olivier, ANDRIANTSITOHAINA, Ramaroson
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological and medical sciences Blotting, Western Carcinogenesis, carcinogens and anticarcinogens Cell Adhesion - drug effects Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Electron Spin Resonance Spectroscopy Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Flow Cytometry Humans Life Sciences Medical sciences Neovascularization, Physiologic Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Phenanthridines - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Superoxides - metabolism Topoisomerase I Inhibitors - pharmacology Tumors Umbilical Veins - cytology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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