Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants
Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical...
Gespeichert in:
| Veröffentlicht in: | The American journal of clinical nutrition 2015-10, Vol.102 (4), p.791-800 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 800 |
|---|---|
| container_issue | 4 |
| container_start_page | 791 |
| container_title | The American journal of clinical nutrition |
| container_volume | 102 |
| creator | Edwards, Cathrina H Grundy, Myriam Ml Grassby, Terri Vasilopoulou, Dafni Frost, Gary S Butterworth, Peter J Berry, Sarah Ee Sanderson, Jeremy Ellis, Peter R |
| description | Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical and biochemical disassembly of cereal food during digestion has not been widely studied.
The aims of this study were to compare the effects of 2 porridge meals prepared from wheat endosperm with different degrees of starch bioaccessibility on postprandial metabolism (e.g., glycemia) and to gain insight into the structural and biochemical breakdown of the test meals during gastroileal transit.
A randomized crossover trial in 9 healthy ileostomy participants was designed to compare the effects of 55 g starch, provided as coarse (2-mm particles) or smooth ( |
| doi_str_mv | 10.3945/ajcn.114.106203 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03232088v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718905318</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-524ef465626970da25450f778c4c7c22b25548281e944fd4634b18cf2b62a73b3</originalsourceid><addsrcrecordid>eNpdkk-P1CAAxYnRuOPq2Zsh8aLJdpZ_pdTbZqOuyRgveiaU0ikTChWoZvyifh1pursHT6Xwe48HPABeY7SnLauv1Un7PcZsjxEniD4BO9xSUVGCmqdghxAiVYt5fQFepHRCCBMm-HNwQTiltMZkB_5-Vd7Oi1PZBg_DAFNWUY-ws0FpbVKynXU2n6H18PdoVIbG9yHNJk4wBxjNcdWaB1lvjyatVldwDinPUfneKgeP7qzNZNVV8UmLs377KavwuGQ4hjgFb4pdmoNPJn2ACq7aMNk_poc6-ByDc2WY4-pX0pQwLo8lmDNlpzCd4axittrOyuf0EjwblEvm1f33Evz49PH77V11-Pb5y-3NodIMoVzVhJmB8ZoT3jaoV6RmNRqaRmimG01IR-qaCSKwaRkbesYp67DQA-k4UQ3t6CV4v_mOysk52knFswzKyrubg1znECXlNYT4hQv7bmPnGH4u5Z7kZJM2zilvwpIkbrBoUU2xKOjb_9BTWKIvJykUQa2gmKNCXW-UjiGlaIbHBBjJtR9y7Ycs_ZBbP4rizb3v0k2mf-QfCkH_AaS3uvo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1720983160</pqid></control><display><type>article</type><title>Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Edwards, Cathrina H ; Grundy, Myriam Ml ; Grassby, Terri ; Vasilopoulou, Dafni ; Frost, Gary S ; Butterworth, Peter J ; Berry, Sarah Ee ; Sanderson, Jeremy ; Ellis, Peter R</creator><creatorcontrib>Edwards, Cathrina H ; Grundy, Myriam Ml ; Grassby, Terri ; Vasilopoulou, Dafni ; Frost, Gary S ; Butterworth, Peter J ; Berry, Sarah Ee ; Sanderson, Jeremy ; Ellis, Peter R</creatorcontrib><description>Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical and biochemical disassembly of cereal food during digestion has not been widely studied.
The aims of this study were to compare the effects of 2 porridge meals prepared from wheat endosperm with different degrees of starch bioaccessibility on postprandial metabolism (e.g., glycemia) and to gain insight into the structural and biochemical breakdown of the test meals during gastroileal transit.
A randomized crossover trial in 9 healthy ileostomy participants was designed to compare the effects of 55 g starch, provided as coarse (2-mm particles) or smooth (<0.2-mm particles) wheat porridge, on postprandial changes in blood glucose, insulin, C-peptide, lipids, and gut hormones and on the resistant starch (RS) content of ileal effluent. Undigested food in the ileal output was examined microscopically to identify cell walls and encapsulated starch.
Blood glucose, insulin, C-peptide, and glucose-dependent insulinotropic polypeptide concentrations were significantly lower (i.e., 33%, 43%, 40%, and 50% lower 120-min incremental AUC, respectively) after consumption of the coarse porridge than after the smooth porridge (P < 0.01). In vitro, starch digestion was slower in the coarse porridge than in the smooth porridge (33% less starch digested at 90 min, P < 0.05, paired t test). In vivo, the structural integrity of coarse particles (∼2 mm) of wheat endosperm was retained during gastroileal transit. Microscopic examination revealed a progressive loss of starch from the periphery toward the particle core. The structure of the test meal had no effect on the amount or pattern of RS output.
The structural integrity of wheat endosperm is largely retained during gastroileal digestion and has a primary role in influencing the rate of starch amylolysis and, consequently, postprandial metabolism. This trial was registered at isrctn.org as ISRCTN40517475.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.114.106203</identifier><identifier>PMID: 26333512</identifier><language>eng</language><publisher>United States: American Society for Clinical Nutrition, Inc</publisher><subject>Adult ; Aged ; Biochemistry ; Blood Glucose - metabolism ; Body Mass Index ; C-Peptide - blood ; Carbohydrates ; Comparative studies ; Cross-Over Studies ; Dietary Carbohydrates - administration & dosage ; Digestion ; Endosperm - chemistry ; Fatty Acids, Nonesterified - blood ; Female ; Food and Nutrition ; Gastric Inhibitory Polypeptide - blood ; Gastrointestinal Hormones ; Healthy Volunteers ; Humans ; Ileostomy ; Insulin - blood ; Life Sciences ; Male ; Metabolism ; Middle Aged ; Polypeptides ; Postprandial Period ; Starch - chemistry ; Triglycerides - blood ; Triticum - chemistry ; Young Adult</subject><ispartof>The American journal of clinical nutrition, 2015-10, Vol.102 (4), p.791-800</ispartof><rights>Copyright American Society for Clinical Nutrition, Inc. Oct 1, 2015</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-524ef465626970da25450f778c4c7c22b25548281e944fd4634b18cf2b62a73b3</citedby><cites>FETCH-LOGICAL-c400t-524ef465626970da25450f778c4c7c22b25548281e944fd4634b18cf2b62a73b3</cites><orcidid>0000-0003-4952-0229 ; 0000-0001-7162-656X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26333512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03232088$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Edwards, Cathrina H</creatorcontrib><creatorcontrib>Grundy, Myriam Ml</creatorcontrib><creatorcontrib>Grassby, Terri</creatorcontrib><creatorcontrib>Vasilopoulou, Dafni</creatorcontrib><creatorcontrib>Frost, Gary S</creatorcontrib><creatorcontrib>Butterworth, Peter J</creatorcontrib><creatorcontrib>Berry, Sarah Ee</creatorcontrib><creatorcontrib>Sanderson, Jeremy</creatorcontrib><creatorcontrib>Ellis, Peter R</creatorcontrib><title>Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical and biochemical disassembly of cereal food during digestion has not been widely studied.
The aims of this study were to compare the effects of 2 porridge meals prepared from wheat endosperm with different degrees of starch bioaccessibility on postprandial metabolism (e.g., glycemia) and to gain insight into the structural and biochemical breakdown of the test meals during gastroileal transit.
A randomized crossover trial in 9 healthy ileostomy participants was designed to compare the effects of 55 g starch, provided as coarse (2-mm particles) or smooth (<0.2-mm particles) wheat porridge, on postprandial changes in blood glucose, insulin, C-peptide, lipids, and gut hormones and on the resistant starch (RS) content of ileal effluent. Undigested food in the ileal output was examined microscopically to identify cell walls and encapsulated starch.
Blood glucose, insulin, C-peptide, and glucose-dependent insulinotropic polypeptide concentrations were significantly lower (i.e., 33%, 43%, 40%, and 50% lower 120-min incremental AUC, respectively) after consumption of the coarse porridge than after the smooth porridge (P < 0.01). In vitro, starch digestion was slower in the coarse porridge than in the smooth porridge (33% less starch digested at 90 min, P < 0.05, paired t test). In vivo, the structural integrity of coarse particles (∼2 mm) of wheat endosperm was retained during gastroileal transit. Microscopic examination revealed a progressive loss of starch from the periphery toward the particle core. The structure of the test meal had no effect on the amount or pattern of RS output.
The structural integrity of wheat endosperm is largely retained during gastroileal digestion and has a primary role in influencing the rate of starch amylolysis and, consequently, postprandial metabolism. This trial was registered at isrctn.org as ISRCTN40517475.</description><subject>Adult</subject><subject>Aged</subject><subject>Biochemistry</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>C-Peptide - blood</subject><subject>Carbohydrates</subject><subject>Comparative studies</subject><subject>Cross-Over Studies</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Digestion</subject><subject>Endosperm - chemistry</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Food and Nutrition</subject><subject>Gastric Inhibitory Polypeptide - blood</subject><subject>Gastrointestinal Hormones</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Ileostomy</subject><subject>Insulin - blood</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Polypeptides</subject><subject>Postprandial Period</subject><subject>Starch - chemistry</subject><subject>Triglycerides - blood</subject><subject>Triticum - chemistry</subject><subject>Young Adult</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkk-P1CAAxYnRuOPq2Zsh8aLJdpZ_pdTbZqOuyRgveiaU0ikTChWoZvyifh1pursHT6Xwe48HPABeY7SnLauv1Un7PcZsjxEniD4BO9xSUVGCmqdghxAiVYt5fQFepHRCCBMm-HNwQTiltMZkB_5-Vd7Oi1PZBg_DAFNWUY-ws0FpbVKynXU2n6H18PdoVIbG9yHNJk4wBxjNcdWaB1lvjyatVldwDinPUfneKgeP7qzNZNVV8UmLs377KavwuGQ4hjgFb4pdmoNPJn2ACq7aMNk_poc6-ByDc2WY4-pX0pQwLo8lmDNlpzCd4axittrOyuf0EjwblEvm1f33Evz49PH77V11-Pb5y-3NodIMoVzVhJmB8ZoT3jaoV6RmNRqaRmimG01IR-qaCSKwaRkbesYp67DQA-k4UQ3t6CV4v_mOysk52knFswzKyrubg1znECXlNYT4hQv7bmPnGH4u5Z7kZJM2zilvwpIkbrBoUU2xKOjb_9BTWKIvJykUQa2gmKNCXW-UjiGlaIbHBBjJtR9y7Ycs_ZBbP4rizb3v0k2mf-QfCkH_AaS3uvo</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Edwards, Cathrina H</creator><creator>Grundy, Myriam Ml</creator><creator>Grassby, Terri</creator><creator>Vasilopoulou, Dafni</creator><creator>Frost, Gary S</creator><creator>Butterworth, Peter J</creator><creator>Berry, Sarah Ee</creator><creator>Sanderson, Jeremy</creator><creator>Ellis, Peter R</creator><general>American Society for Clinical Nutrition, Inc</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-4952-0229</orcidid><orcidid>https://orcid.org/0000-0001-7162-656X</orcidid></search><sort><creationdate>20151001</creationdate><title>Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants</title><author>Edwards, Cathrina H ; Grundy, Myriam Ml ; Grassby, Terri ; Vasilopoulou, Dafni ; Frost, Gary S ; Butterworth, Peter J ; Berry, Sarah Ee ; Sanderson, Jeremy ; Ellis, Peter R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-524ef465626970da25450f778c4c7c22b25548281e944fd4634b18cf2b62a73b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biochemistry</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>C-Peptide - blood</topic><topic>Carbohydrates</topic><topic>Comparative studies</topic><topic>Cross-Over Studies</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Digestion</topic><topic>Endosperm - chemistry</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Food and Nutrition</topic><topic>Gastric Inhibitory Polypeptide - blood</topic><topic>Gastrointestinal Hormones</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Ileostomy</topic><topic>Insulin - blood</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Polypeptides</topic><topic>Postprandial Period</topic><topic>Starch - chemistry</topic><topic>Triglycerides - blood</topic><topic>Triticum - chemistry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edwards, Cathrina H</creatorcontrib><creatorcontrib>Grundy, Myriam Ml</creatorcontrib><creatorcontrib>Grassby, Terri</creatorcontrib><creatorcontrib>Vasilopoulou, Dafni</creatorcontrib><creatorcontrib>Frost, Gary S</creatorcontrib><creatorcontrib>Butterworth, Peter J</creatorcontrib><creatorcontrib>Berry, Sarah Ee</creatorcontrib><creatorcontrib>Sanderson, Jeremy</creatorcontrib><creatorcontrib>Ellis, Peter R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edwards, Cathrina H</au><au>Grundy, Myriam Ml</au><au>Grassby, Terri</au><au>Vasilopoulou, Dafni</au><au>Frost, Gary S</au><au>Butterworth, Peter J</au><au>Berry, Sarah Ee</au><au>Sanderson, Jeremy</au><au>Ellis, Peter R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>102</volume><issue>4</issue><spage>791</spage><epage>800</epage><pages>791-800</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical and biochemical disassembly of cereal food during digestion has not been widely studied.
The aims of this study were to compare the effects of 2 porridge meals prepared from wheat endosperm with different degrees of starch bioaccessibility on postprandial metabolism (e.g., glycemia) and to gain insight into the structural and biochemical breakdown of the test meals during gastroileal transit.
A randomized crossover trial in 9 healthy ileostomy participants was designed to compare the effects of 55 g starch, provided as coarse (2-mm particles) or smooth (<0.2-mm particles) wheat porridge, on postprandial changes in blood glucose, insulin, C-peptide, lipids, and gut hormones and on the resistant starch (RS) content of ileal effluent. Undigested food in the ileal output was examined microscopically to identify cell walls and encapsulated starch.
Blood glucose, insulin, C-peptide, and glucose-dependent insulinotropic polypeptide concentrations were significantly lower (i.e., 33%, 43%, 40%, and 50% lower 120-min incremental AUC, respectively) after consumption of the coarse porridge than after the smooth porridge (P < 0.01). In vitro, starch digestion was slower in the coarse porridge than in the smooth porridge (33% less starch digested at 90 min, P < 0.05, paired t test). In vivo, the structural integrity of coarse particles (∼2 mm) of wheat endosperm was retained during gastroileal transit. Microscopic examination revealed a progressive loss of starch from the periphery toward the particle core. The structure of the test meal had no effect on the amount or pattern of RS output.
The structural integrity of wheat endosperm is largely retained during gastroileal digestion and has a primary role in influencing the rate of starch amylolysis and, consequently, postprandial metabolism. This trial was registered at isrctn.org as ISRCTN40517475.</abstract><cop>United States</cop><pub>American Society for Clinical Nutrition, Inc</pub><pmid>26333512</pmid><doi>10.3945/ajcn.114.106203</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4952-0229</orcidid><orcidid>https://orcid.org/0000-0001-7162-656X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2015-10, Vol.102 (4), p.791-800 |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03232088v1 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Biochemistry Blood Glucose - metabolism Body Mass Index C-Peptide - blood Carbohydrates Comparative studies Cross-Over Studies Dietary Carbohydrates - administration & dosage Digestion Endosperm - chemistry Fatty Acids, Nonesterified - blood Female Food and Nutrition Gastric Inhibitory Polypeptide - blood Gastrointestinal Hormones Healthy Volunteers Humans Ileostomy Insulin - blood Life Sciences Male Metabolism Middle Aged Polypeptides Postprandial Period Starch - chemistry Triglycerides - blood Triticum - chemistry Young Adult |
| title | Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T05%3A26%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Manipulation%20of%20starch%20bioaccessibility%20in%20wheat%20endosperm%20to%20regulate%20starch%20digestion,%20postprandial%20glycemia,%20insulinemia,%20and%20gut%20hormone%20responses:%20a%20randomized%20controlled%20trial%20in%20healthy%20ileostomy%20participants&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=Edwards,%20Cathrina%20H&rft.date=2015-10-01&rft.volume=102&rft.issue=4&rft.spage=791&rft.epage=800&rft.pages=791-800&rft.issn=0002-9165&rft.eissn=1938-3207&rft_id=info:doi/10.3945/ajcn.114.106203&rft_dat=%3Cproquest_hal_p%3E1718905318%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1720983160&rft_id=info:pmid/26333512&rfr_iscdi=true |