Nuclear translocation of MRTFA in MCF7 breast cancer cells shifts ERα nuclear/genomic to extra-nuclear/non genomic actions

The Myocardin-related transcription factor A [MRTFA, also known as Megakaryoblastic Leukemia 1 (MKL1))] is a major actor in the epithelial to mesenchymal transition (EMT). We have previously shown that activation and nuclear accumulation of MRTFA mediate endocrine resistance of estrogen receptor alp...

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Veröffentlicht in:	Molecular and cellular endocrinology 2021-06, Vol.530, p.111282-111282, Article 111282
Hauptverfasser:	Jehanno, Charly, Percevault, Frédéric, Boujrad, Noureddine, Le Goff, Pascale, Fontaine, Coralie, Arnal, Jean-François, Primig, Michael, Pakdel, Farzad, Michel, Denis, Métivier, Raphaël, Flouriot, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Breast cancer Cancer Endocrine resistance Estrogen receptor Genomics Life Sciences MRTFA NCOR1 P160 family coactivators PI3K SMRT src
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