Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

Background and Aims Cenicriviroc (CVC) is a C‐C chemokine receptors type 2 and 5 dual antagonist under evaluation for treating liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). Year 1 primary analysis of the 2‐year CENTAUR study showed that CVC had an antifibrotic effect without imp...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-09, Vol.72 (3), p.892-905
Hauptverfasser:	Ratziu, Vlad, Sanyal, Arun, Harrison, Stephen A., Wong, Vincent Wai‐Sun, Francque, Sven, Goodman, Zachary, Aithal, Guruprasad P., Kowdley, Kris V., Seyedkazemi, Star, Fischer, Laurent, Loomba, Rohit, Abdelmalek, Manal F., Tacke, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartate aminotransferase Aspartate Aminotransferases Aspartate Aminotransferases - blood Biopsy Biopsy - methods CCR5 Receptor Antagonists CCR5 Receptor Antagonists - administration & dosage CCR5 Receptor Antagonists - adverse effects Chemokine receptors Collagen Disease Progression Drug Monitoring Drug Monitoring - methods Fatty liver Female Fibrosis Hepatology Humans Imidazoles Imidazoles - administration & dosage Imidazoles - adverse effects Life Sciences Liver Liver - pathology Liver Cirrhosis Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology Liver Cirrhosis - prevention & control Liver diseases Male Middle Aged Non-alcoholic Fatty Liver Disease Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - drug therapy Patient Acuity Patients Platelet Count Platelet Count - methods Receptors, CCR2 Receptors, CCR2 - metabolism Sulfoxides Sulfoxides - administration & dosage Sulfoxides - adverse effects Treatment Outcome
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