Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian sys...
Gespeichert in:
| Veröffentlicht in: | Neurochemical research 2021-07, Vol.46 (7), p.1603-1617 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1617 |
|---|---|
| container_issue | 7 |
| container_start_page | 1603 |
| container_title | Neurochemical research |
| container_volume | 46 |
| creator | Uddin, Md. Sahab Sumsuzzman, Dewan Md Jeandet, Philippe Behl, Tapan Rauf, Abdur Amran, Md. Shah Ashraf, Ghulam Md |
| description | Alzheimer’s disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis. |
| doi_str_mv | 10.1007/s11064-021-03325-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03210661v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2515075596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-7e94ff755b7272e53e0ac2ec8db3ee5803e57fda8b88262d7ecacab9c9894e593</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERW8LL8ACRWJDF4GxfR3by6tbSivdig1I7CzHmRBX-cNOUGHFa_T1eBIcUorEgpVlz3fOjOcQ8pzCawog30RKodjmwGgOnDOR3z4iGyokzwsN_DHZAE9lTjUck5MYbwCSjNEn5JhzJanUekM-naPzY4PB95-zqcHsqp8wWDct92t0je197GI21NneB2crb_vs3Mcwj5Mf-sz2VbZrvzfoOww_f9zFpYg24lNyVNs24rP785R8vHj7YX-ZH96_u9rvDrnbgp5yiXpb11KIUjLJUHAE6xg6VZUcUSjgKGRdWVUqxQpWSXTW2VI7rfQWhean5Gz1bWxrxuA7G76ZwXpzuTuY5Q04S2sq6Fea2FcrO4bhy4xxMp2PDtvW9jjM0TBBBaRZdJHQl_-gN8Mc-vSTRHGlpBawUGylXBhiDFg_TEDBLBmZNSOT1m5-Z2Ruk-jFvfVcdlg9SP6EkgC-AnFcYsHwt_d_bH8BvQSdMA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2538879506</pqid></control><display><type>article</type><title>Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease</title><source>Springer Nature - Complete Springer Journals</source><creator>Uddin, Md. Sahab ; Sumsuzzman, Dewan Md ; Jeandet, Philippe ; Behl, Tapan ; Rauf, Abdur ; Amran, Md. Shah ; Ashraf, Ghulam Md</creator><creatorcontrib>Uddin, Md. Sahab ; Sumsuzzman, Dewan Md ; Jeandet, Philippe ; Behl, Tapan ; Rauf, Abdur ; Amran, Md. Shah ; Ashraf, Ghulam Md</creatorcontrib><description>Alzheimer’s disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-021-03325-x</identifier><identifier>PMID: 33871799</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Biochemistry ; Biological clocks ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Circadian rhythm ; Circadian rhythms ; Dementia ; Dementia disorders ; Disruption ; Life Sciences ; Molecular modelling ; Neurochemistry ; Neurodegenerative diseases ; Neurofibrillary tangles ; Neurology ; Neurosciences ; Pathogenesis ; Plaques ; Review ; Sleep ; Sleep and wakefulness</subject><ispartof>Neurochemical research, 2021-07, Vol.46 (7), p.1603-1617</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-7e94ff755b7272e53e0ac2ec8db3ee5803e57fda8b88262d7ecacab9c9894e593</citedby><cites>FETCH-LOGICAL-c409t-7e94ff755b7272e53e0ac2ec8db3ee5803e57fda8b88262d7ecacab9c9894e593</cites><orcidid>0000-0002-0805-7840 ; 0000-0003-3023-4871 ; 0000-0003-2429-5491</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-021-03325-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-021-03325-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33871799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-reims.fr/hal-03210661$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Uddin, Md. Sahab</creatorcontrib><creatorcontrib>Sumsuzzman, Dewan Md</creatorcontrib><creatorcontrib>Jeandet, Philippe</creatorcontrib><creatorcontrib>Behl, Tapan</creatorcontrib><creatorcontrib>Rauf, Abdur</creatorcontrib><creatorcontrib>Amran, Md. Shah</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><title>Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Alzheimer’s disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.</description><subject>Alzheimer's disease</subject><subject>Biochemistry</subject><subject>Biological clocks</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Circadian rhythm</subject><subject>Circadian rhythms</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Disruption</subject><subject>Life Sciences</subject><subject>Molecular modelling</subject><subject>Neurochemistry</subject><subject>Neurodegenerative diseases</subject><subject>Neurofibrillary tangles</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Pathogenesis</subject><subject>Plaques</subject><subject>Review</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhS1ERW8LL8ACRWJDF4GxfR3by6tbSivdig1I7CzHmRBX-cNOUGHFa_T1eBIcUorEgpVlz3fOjOcQ8pzCawog30RKodjmwGgOnDOR3z4iGyokzwsN_DHZAE9lTjUck5MYbwCSjNEn5JhzJanUekM-naPzY4PB95-zqcHsqp8wWDct92t0je197GI21NneB2crb_vs3Mcwj5Mf-sz2VbZrvzfoOww_f9zFpYg24lNyVNs24rP785R8vHj7YX-ZH96_u9rvDrnbgp5yiXpb11KIUjLJUHAE6xg6VZUcUSjgKGRdWVUqxQpWSXTW2VI7rfQWhean5Gz1bWxrxuA7G76ZwXpzuTuY5Q04S2sq6Fea2FcrO4bhy4xxMp2PDtvW9jjM0TBBBaRZdJHQl_-gN8Mc-vSTRHGlpBawUGylXBhiDFg_TEDBLBmZNSOT1m5-Z2Ruk-jFvfVcdlg9SP6EkgC-AnFcYsHwt_d_bH8BvQSdMA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Uddin, Md. Sahab</creator><creator>Sumsuzzman, Dewan Md</creator><creator>Jeandet, Philippe</creator><creator>Behl, Tapan</creator><creator>Rauf, Abdur</creator><creator>Amran, Md. Shah</creator><creator>Ashraf, Ghulam Md</creator><general>Springer US</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0805-7840</orcidid><orcidid>https://orcid.org/0000-0003-3023-4871</orcidid><orcidid>https://orcid.org/0000-0003-2429-5491</orcidid></search><sort><creationdate>20210701</creationdate><title>Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease</title><author>Uddin, Md. Sahab ; Sumsuzzman, Dewan Md ; Jeandet, Philippe ; Behl, Tapan ; Rauf, Abdur ; Amran, Md. Shah ; Ashraf, Ghulam Md</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-7e94ff755b7272e53e0ac2ec8db3ee5803e57fda8b88262d7ecacab9c9894e593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Biochemistry</topic><topic>Biological clocks</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Circadian rhythm</topic><topic>Circadian rhythms</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Disruption</topic><topic>Life Sciences</topic><topic>Molecular modelling</topic><topic>Neurochemistry</topic><topic>Neurodegenerative diseases</topic><topic>Neurofibrillary tangles</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Pathogenesis</topic><topic>Plaques</topic><topic>Review</topic><topic>Sleep</topic><topic>Sleep and wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uddin, Md. Sahab</creatorcontrib><creatorcontrib>Sumsuzzman, Dewan Md</creatorcontrib><creatorcontrib>Jeandet, Philippe</creatorcontrib><creatorcontrib>Behl, Tapan</creatorcontrib><creatorcontrib>Rauf, Abdur</creatorcontrib><creatorcontrib>Amran, Md. Shah</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uddin, Md. Sahab</au><au>Sumsuzzman, Dewan Md</au><au>Jeandet, Philippe</au><au>Behl, Tapan</au><au>Rauf, Abdur</au><au>Amran, Md. Shah</au><au>Ashraf, Ghulam Md</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>46</volume><issue>7</issue><spage>1603</spage><epage>1617</epage><pages>1603-1617</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Alzheimer’s disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33871799</pmid><doi>10.1007/s11064-021-03325-x</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-0805-7840</orcidid><orcidid>https://orcid.org/0000-0003-3023-4871</orcidid><orcidid>https://orcid.org/0000-0003-2429-5491</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2021-07, Vol.46 (7), p.1603-1617 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03210661v1 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Alzheimer's disease Biochemistry Biological clocks Biomedical and Life Sciences Biomedicine Cell Biology Circadian rhythm Circadian rhythms Dementia Dementia disorders Disruption Life Sciences Molecular modelling Neurochemistry Neurodegenerative diseases Neurofibrillary tangles Neurology Neurosciences Pathogenesis Plaques Review Sleep Sleep and wakefulness |
| title | Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T10%3A34%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deciphering%20the%20Interacting%20Mechanisms%20of%20Circadian%20Disruption%20and%20Alzheimer%E2%80%99s%20Disease&rft.jtitle=Neurochemical%20research&rft.au=Uddin,%20Md.%20Sahab&rft.date=2021-07-01&rft.volume=46&rft.issue=7&rft.spage=1603&rft.epage=1617&rft.pages=1603-1617&rft.issn=0364-3190&rft.eissn=1573-6903&rft_id=info:doi/10.1007/s11064-021-03325-x&rft_dat=%3Cproquest_hal_p%3E2515075596%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2538879506&rft_id=info:pmid/33871799&rfr_iscdi=true |