Unique Subcellular Distribution of Five Annexins in Resting and Insulin-Stimulated Rat Adipose Cells
Several lines of evidence suggest that annexins, a family of phospholipid-binding proteins, play a role in cellular trafficking. Five annexins (I, II, V, VI, VII) were detected in rat adipose cells. They were primarily associated with the plasma membrane in a calcium-dependent manner. None of them r...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1996-08, Vol.225 (1), p.116-121 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Raynal, Patrick Pollard, Harvey B. Cushman, Samuel W. Guerre-Millo, Michèle |
| description | Several lines of evidence suggest that annexins, a family of phospholipid-binding proteins, play a role in cellular trafficking. Five annexins (I, II, V, VI, VII) were detected in rat adipose cells. They were primarily associated with the plasma membrane in a calcium-dependent manner. None of them redistributed with insulin treatment of the cells, in contrast to the glucose transporter GLUT4, which moved from intracellular membranes to the plasma membrane. Although the actual function of annexins in adipose cells remains to be determined, our data indicate that insulin-stimulated GLUT4 trafficking does not rely on a change in subcellular location of any of the five annexins detected so far in these cells. |
| doi_str_mv | 10.1006/bbrc.1996.1139 |
| format | Article |
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Five annexins (I, II, V, VI, VII) were detected in rat adipose cells. They were primarily associated with the plasma membrane in a calcium-dependent manner. None of them redistributed with insulin treatment of the cells, in contrast to the glucose transporter GLUT4, which moved from intracellular membranes to the plasma membrane. 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Five annexins (I, II, V, VI, VII) were detected in rat adipose cells. They were primarily associated with the plasma membrane in a calcium-dependent manner. None of them redistributed with insulin treatment of the cells, in contrast to the glucose transporter GLUT4, which moved from intracellular membranes to the plasma membrane. Although the actual function of annexins in adipose cells remains to be determined, our data indicate that insulin-stimulated GLUT4 trafficking does not rely on a change in subcellular location of any of the five annexins detected so far in these cells.</description><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - ultrastructure</subject><subject>Animals</subject><subject>Annexins - drug effects</subject><subject>Annexins - metabolism</subject><subject>Epididymis</subject><subject>Glucose Transporter Type 4</subject><subject>Immunoblotting</subject><subject>Insulin - pharmacology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Monosaccharide Transport Proteins - drug effects</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Subcellular Fractions - drug effects</subject><subject>Subcellular Fractions - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2LFDEQhoMo67h69SbkJHjosao_pjvHYXTdhQFh1wVvIZ1Ua0lPekzSg_5708ywN3MpSD31HN5XiLcIawTYfOz7YNeo1GaNWKlnYoWgoCgR6udiBZkoSoXfX4pXMf4CQKw36kpcde1GIVQr4R49_55JPsy9pXGcRxPkJ44pcD8nnrycBnnDJ5Jb7-kP-yjZy3uKif0PabyTdz7OI_viIfEhXydy8t4kuXV8nCLJXZbG1-LFYMZIby7zWjzefP62uy32X7_c7bb7wlZtlQrsewfQNYS2AYsDOOPaYSjLgZpOGdNCVSGWzlqqG8RBEZgaayRjoGwcVdfiw9n704z6GPhgwl89Gda3271e_qBCVWLXnjCz78_sMUw5gJj0geMSgfE0zVG3XZlf3WZwfQZtmGIMNDyZEfRSgV4q0EsFeqkgH7y7mOf-QO4Jv2Se9915TzmKE1PQ0TJ5S44D2aTdxP9T_wOTKpWN</recordid><startdate>19960805</startdate><enddate>19960805</enddate><creator>Raynal, Patrick</creator><creator>Pollard, Harvey B.</creator><creator>Cushman, Samuel W.</creator><creator>Guerre-Millo, Michèle</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6731-3007</orcidid></search><sort><creationdate>19960805</creationdate><title>Unique Subcellular Distribution of Five Annexins in Resting and Insulin-Stimulated Rat Adipose Cells</title><author>Raynal, Patrick ; Pollard, Harvey B. ; Cushman, Samuel W. ; Guerre-Millo, Michèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-1bbd0085e1c50c1f0dad7ff22fe589aa7033112dcce4511f9e0a4141eaa025de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - ultrastructure</topic><topic>Animals</topic><topic>Annexins - drug effects</topic><topic>Annexins - metabolism</topic><topic>Epididymis</topic><topic>Glucose Transporter Type 4</topic><topic>Immunoblotting</topic><topic>Insulin - pharmacology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Monosaccharide Transport Proteins - drug effects</topic><topic>Monosaccharide Transport Proteins - metabolism</topic><topic>Muscle Proteins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Subcellular Fractions - drug effects</topic><topic>Subcellular Fractions - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raynal, Patrick</creatorcontrib><creatorcontrib>Pollard, Harvey B.</creatorcontrib><creatorcontrib>Cushman, Samuel W.</creatorcontrib><creatorcontrib>Guerre-Millo, Michèle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raynal, Patrick</au><au>Pollard, Harvey B.</au><au>Cushman, Samuel W.</au><au>Guerre-Millo, Michèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unique Subcellular Distribution of Five Annexins in Resting and Insulin-Stimulated Rat Adipose Cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1996-08-05</date><risdate>1996</risdate><volume>225</volume><issue>1</issue><spage>116</spage><epage>121</epage><pages>116-121</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Several lines of evidence suggest that annexins, a family of phospholipid-binding proteins, play a role in cellular trafficking. Five annexins (I, II, V, VI, VII) were detected in rat adipose cells. They were primarily associated with the plasma membrane in a calcium-dependent manner. None of them redistributed with insulin treatment of the cells, in contrast to the glucose transporter GLUT4, which moved from intracellular membranes to the plasma membrane. Although the actual function of annexins in adipose cells remains to be determined, our data indicate that insulin-stimulated GLUT4 trafficking does not rely on a change in subcellular location of any of the five annexins detected so far in these cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8769103</pmid><doi>10.1006/bbrc.1996.1139</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6731-3007</orcidid></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1996-08, Vol.225 (1), p.116-121 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - ultrastructure Animals Annexins - drug effects Annexins - metabolism Epididymis Glucose Transporter Type 4 Immunoblotting Insulin - pharmacology Life Sciences Male Monosaccharide Transport Proteins - drug effects Monosaccharide Transport Proteins - metabolism Muscle Proteins Rats Rats, Sprague-Dawley Subcellular Fractions - drug effects Subcellular Fractions - metabolism |
| title | Unique Subcellular Distribution of Five Annexins in Resting and Insulin-Stimulated Rat Adipose Cells |
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