Immunohistochemical study of DNA topoisomerase I, DNA topoisomerase IIα, p53, and Ki-67 in oral preneoplastic lesions and oral squamous cell carcinomas

Human DNA topoisomerase I (topo I) is the molecular target of the camptothecin group of anticancer drugs. Laboratory studies have shown that the cellular response to topo I-targeted drugs depends on the topo I expression and DNA replication rate and the apoptotic pathway activity. In this study, we...

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Veröffentlicht in:	Human pathology 2004-06, Vol.35 (6), p.745-751
Hauptverfasser:	Hafian, Hilal, Venteo, Lydie, Sukhanova, Alyona, Nabiev, Igor, Lefevre, Benoı̂t, Pluot, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Neoplasm Biochemistry, Molecular Biology Biological and medical sciences Biomarkers, Tumor - analysis Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology DNA topoisomerase I DNA topoisomerase II-alpha DNA Topoisomerases, Type I - biosynthesis DNA Topoisomerases, Type II - biosynthesis DNA-Binding Proteins Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Ki-67 Antigen - biosynthesis Life Sciences Male Medical sciences Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - pathology oral intraepithelial neoplasia (OIN) oral squamous cell carcinoma Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Precancerous Conditions - metabolism Precancerous Conditions - pathology Tumor Suppressor Protein p53 - biosynthesis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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