Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms
Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amp...
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| Veröffentlicht in: | International journal of pharmaceutics 2010-08, Vol.396 (1), p.204-209 |
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| container_title | International journal of pharmaceutics |
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| creator | Perrier, Thomas Saulnier, Patrick Fouchet, Florian Lautram, Nolwenn Benoît, Jean-Pierre |
| description | Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms. |
| doi_str_mv | 10.1016/j.ijpharm.2010.06.019 |
| format | Article |
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Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. 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Drug treatments ; Phosphatidylethanolamines - chemistry ; Polyethylene Glycols - chemistry ; Post-insertion ; Soft-particle analysis ; Stearic Acids - chemistry ; Surface-Active Agents - chemistry ; Technology, Pharmaceutical - methods ; Temperature ; Time Factors ; Triglycerides - chemistry</subject><ispartof>International journal of pharmaceutics, 2010-08, Vol.396 (1), p.204-209</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-55efe71ec7f3a359fe1294f98b128ebf5c3c76ea14804dce2912f43191a0e7f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2010.06.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23086658$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20600733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-angers.hal.science/hal-03171893$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Perrier, Thomas</creatorcontrib><creatorcontrib>Saulnier, Patrick</creatorcontrib><creatorcontrib>Fouchet, Florian</creatorcontrib><creatorcontrib>Lautram, Nolwenn</creatorcontrib><creatorcontrib>Benoît, Jean-Pierre</creatorcontrib><title>Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms.</description><subject>Amphiphilic phospholipids</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Carriers</subject><subject>Drug Compounding</subject><subject>Electrokinetic measurements</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>General pharmacology</subject><subject>Life Sciences</subject><subject>Lipid NanoCapsules</subject><subject>Lipids - chemistry</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nanocapsules</subject><subject>Nanotechnology</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylethanolamines - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Post-insertion</subject><subject>Soft-particle analysis</subject><subject>Stearic Acids - chemistry</subject><subject>Surface-Active Agents - chemistry</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Triglycerides - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi1ERZeFRwDlgqCHLOM4sZNeULWitFLUcgCultcZa71K4uDJVvD2eLVLe-zJ0uj7x7_mY-wdhxUHLj_vVn43bU0cVgWkGcgV8OYFW_BaiVyUSr5kCxCqziuuxDl7TbQDAFlw8YqdFyABlBAL9ut7oDn3I2GcfRgzP84ha_3ku-zOjGFtJtr3SNmn9m5NF5fZdQxDhn8mjH7AcTZ9ZmhCO1OWcgParRk9DfSGnTnTE749vUv28_rrj_VN3t5_u11ftbktJcx5VaFDxdEqJ4yoGoe8aErX1Bte1LhxlRVWSTS8rKHsLBYNL1wpeMMNoHIgluziuHdrej2lTib-1cF4fXPV6sMMBFe8bsQDT-zHIzvF8HuPNOvBk8W-NyOGPWlVlZUsoYDnybIBrop0wCWrjqSNgSiieyzBQR886Z0-edIHTxqkTp5S7v3ph_1mwO4x9V9MAj6cAEPW9C6a0Xp64gTUUlZ14r4cOUxXfvAYNVmPo8XOx6RFd8E_U-UfiiqyDQ</recordid><startdate>20100830</startdate><enddate>20100830</enddate><creator>Perrier, Thomas</creator><creator>Saulnier, Patrick</creator><creator>Fouchet, Florian</creator><creator>Lautram, Nolwenn</creator><creator>Benoît, Jean-Pierre</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope></search><sort><creationdate>20100830</creationdate><title>Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms</title><author>Perrier, Thomas ; Saulnier, Patrick ; Fouchet, Florian ; Lautram, Nolwenn ; Benoît, Jean-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-55efe71ec7f3a359fe1294f98b128ebf5c3c76ea14804dce2912f43191a0e7f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amphiphilic phospholipids</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Carriers</topic><topic>Drug Compounding</topic><topic>Electrokinetic measurements</topic><topic>Electrophoretic Mobility Shift Assay</topic><topic>General pharmacology</topic><topic>Life Sciences</topic><topic>Lipid NanoCapsules</topic><topic>Lipids - chemistry</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nanocapsules</topic><topic>Nanotechnology</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylethanolamines - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Post-insertion</topic><topic>Soft-particle analysis</topic><topic>Stearic Acids - chemistry</topic><topic>Surface-Active Agents - chemistry</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Triglycerides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrier, Thomas</creatorcontrib><creatorcontrib>Saulnier, Patrick</creatorcontrib><creatorcontrib>Fouchet, Florian</creatorcontrib><creatorcontrib>Lautram, Nolwenn</creatorcontrib><creatorcontrib>Benoît, Jean-Pierre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrier, Thomas</au><au>Saulnier, Patrick</au><au>Fouchet, Florian</au><au>Lautram, Nolwenn</au><au>Benoît, Jean-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2010-08-30</date><risdate>2010</risdate><volume>396</volume><issue>1</issue><spage>204</spage><epage>209</epage><pages>204-209</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20600733</pmid><doi>10.1016/j.ijpharm.2010.06.019</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2010-08, Vol.396 (1), p.204-209 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amphiphilic phospholipids Biological and medical sciences Chemistry, Pharmaceutical Drug Carriers Drug Compounding Electrokinetic measurements Electrophoretic Mobility Shift Assay General pharmacology Life Sciences Lipid NanoCapsules Lipids - chemistry Medical sciences Molecular Structure Nanocapsules Nanotechnology Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylethanolamines - chemistry Polyethylene Glycols - chemistry Post-insertion Soft-particle analysis Stearic Acids - chemistry Surface-Active Agents - chemistry Technology, Pharmaceutical - methods Temperature Time Factors Triglycerides - chemistry |
| title | Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms |
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