Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression
In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as p...
Gespeichert in:
| Veröffentlicht in: | Reviews of physiology, biochemistry and pharmacology biochemistry and pharmacology, 2021-01, Vol.181, p.1-38 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 38 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | Reviews of physiology, biochemistry and pharmacology |
| container_volume | 181 |
| creator | Ouadid-Ahidouch, Halima Morjani, Hamid Schnipper, Julie Girault, Alban Ahidouch, Ahmed |
| description | In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer. |
| doi_str_mv | 10.1007/112_2020_19 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03164510v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EBC6838857_5_9</sourcerecordid><originalsourceid>FETCH-LOGICAL-h320t-d4c7a6c86e18d5bdf50054a22d46f65af6adfdc0fa202c493161e64d9e989d3e3</originalsourceid><addsrcrecordid>eNpdkUlv2zAQhdk9TupT74GO7UHtcBGX3lLDbQwYSA_pqQeCpoaRWkl0STlA_n0ZxF2QA0Fi3sc3mDeEvKHwngKoD5Qyy4CBpeYJWRqlOXAwYBjop2RBJVV1o7R8Rk6PAjXwnCzKm9eCCXhJTikzoJjgzJyQZc4_AIApVhzEK3LCmZJUNGpBvq9DQD_nKoZq7rC6PowxVevptk9xGnGaqzhVm3JWnZsmHPLHajPuh967uS_VUOBPCV2eq5WbPKbqa4o3CXMu6mvyIrgh4_J4n5Fvn9fXq8t6e_Vls7rY1h1nMNet8MpJryVS3Ta7NjQAjXCMtUIG2bggXRtaD8GVSLwwvMyPUrQGjTYtR35G3j34dm6w-9SPLt3Z6Hp7ebG19zUoX0RD4ZYW9u0Du0_x1wHzbMc-exwGN2E8ZFsSo5pKJmVBz4_oYTdi-9f5T3j_-uYiTTeY7C7Gn9nSsreyRfvfFgsLj_riPexLwskNvnP7GVO2UnOtG2Uba_hv5DeU2g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>EBC6838857_5_9</pqid></control><display><type>article</type><title>Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ouadid-Ahidouch, Halima ; Morjani, Hamid ; Schnipper, Julie ; Girault, Alban ; Ahidouch, Ahmed</creator><contributor>Pardo, Luis A ; Stock, Christian ; Pardo, Luis A. ; Stock, Christian</contributor><creatorcontrib>Ouadid-Ahidouch, Halima ; Morjani, Hamid ; Schnipper, Julie ; Girault, Alban ; Ahidouch, Ahmed ; Pardo, Luis A ; Stock, Christian ; Pardo, Luis A. ; Stock, Christian</creatorcontrib><description>In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer.</description><identifier>ISSN: 0303-4240</identifier><identifier>ISSN: 1386-1425</identifier><identifier>ISBN: 3030909190</identifier><identifier>ISBN: 9783030909192</identifier><identifier>EISSN: 1617-5786</identifier><identifier>EISSN: 1873-3557</identifier><identifier>EISBN: 9783030909208</identifier><identifier>EISBN: 3030909204</identifier><identifier>DOI: 10.1007/112_2020_19</identifier><identifier>OCLC: 1290724329</identifier><identifier>PMID: 32761457</identifier><identifier>LCCallNum: R850.A1-854</identifier><language>eng</language><publisher>Switzerland: Springer International Publishing AG</publisher><subject>ATP ; Biochemistry, Molecular Biology ; Biological Physics ; Biophysics ; Breast cancer ; Breast Neoplasms ; Cancer ; Cell Behavior ; Cellular Biology ; Collagen 1 ; EGF ; Engineering Sciences ; Female ; Humans ; Hypoxia ; Ion Channels ; Life Sciences ; Optics ; Photonic ; Physics ; Signal and Image processing ; Signal Transduction ; Subcellular Processes ; TGF-β ; Transforming Growth Factor beta - metabolism ; Tumor Microenvironment</subject><ispartof>Reviews of physiology, biochemistry and pharmacology, 2021-01, Vol.181, p.1-38</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>2020. Springer Nature Switzerland AG.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7869-5242 ; 0000-0003-1959-7807 ; 0000-0002-1100-8759 ; 0000-0003-1520-6127 ; 0000-0002-4315-6043 ; 0009-0000-9765-6222 ; 0000-0002-1959-326X ; 0000-0001-5478-9340</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://ebookcentral.proquest.com/covers/6838857-l.jpg</thumbnail><link.rule.ids>230,314,779,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32761457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03164510$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Pardo, Luis A</contributor><contributor>Stock, Christian</contributor><contributor>Pardo, Luis A.</contributor><contributor>Stock, Christian</contributor><creatorcontrib>Ouadid-Ahidouch, Halima</creatorcontrib><creatorcontrib>Morjani, Hamid</creatorcontrib><creatorcontrib>Schnipper, Julie</creatorcontrib><creatorcontrib>Girault, Alban</creatorcontrib><creatorcontrib>Ahidouch, Ahmed</creatorcontrib><title>Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression</title><title>Reviews of physiology, biochemistry and pharmacology</title><addtitle>Rev Physiol Biochem Pharmacol</addtitle><description>In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer.</description><subject>ATP</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological Physics</subject><subject>Biophysics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms</subject><subject>Cancer</subject><subject>Cell Behavior</subject><subject>Cellular Biology</subject><subject>Collagen 1</subject><subject>EGF</subject><subject>Engineering Sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Ion Channels</subject><subject>Life Sciences</subject><subject>Optics</subject><subject>Photonic</subject><subject>Physics</subject><subject>Signal and Image processing</subject><subject>Signal Transduction</subject><subject>Subcellular Processes</subject><subject>TGF-β</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Tumor Microenvironment</subject><issn>0303-4240</issn><issn>1386-1425</issn><issn>1617-5786</issn><issn>1873-3557</issn><isbn>3030909190</isbn><isbn>9783030909192</isbn><isbn>9783030909208</isbn><isbn>3030909204</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUlv2zAQhdk9TupT74GO7UHtcBGX3lLDbQwYSA_pqQeCpoaRWkl0STlA_n0ZxF2QA0Fi3sc3mDeEvKHwngKoD5Qyy4CBpeYJWRqlOXAwYBjop2RBJVV1o7R8Rk6PAjXwnCzKm9eCCXhJTikzoJjgzJyQZc4_AIApVhzEK3LCmZJUNGpBvq9DQD_nKoZq7rC6PowxVevptk9xGnGaqzhVm3JWnZsmHPLHajPuh967uS_VUOBPCV2eq5WbPKbqa4o3CXMu6mvyIrgh4_J4n5Fvn9fXq8t6e_Vls7rY1h1nMNet8MpJryVS3Ta7NjQAjXCMtUIG2bggXRtaD8GVSLwwvMyPUrQGjTYtR35G3j34dm6w-9SPLt3Z6Hp7ebG19zUoX0RD4ZYW9u0Du0_x1wHzbMc-exwGN2E8ZFsSo5pKJmVBz4_oYTdi-9f5T3j_-uYiTTeY7C7Gn9nSsreyRfvfFgsLj_riPexLwskNvnP7GVO2UnOtG2Uba_hv5DeU2g</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Ouadid-Ahidouch, Halima</creator><creator>Morjani, Hamid</creator><creator>Schnipper, Julie</creator><creator>Girault, Alban</creator><creator>Ahidouch, Ahmed</creator><general>Springer International Publishing AG</general><general>Springer International Publishing</general><general>Elsevier</general><scope>FFUUA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7869-5242</orcidid><orcidid>https://orcid.org/0000-0003-1959-7807</orcidid><orcidid>https://orcid.org/0000-0002-1100-8759</orcidid><orcidid>https://orcid.org/0000-0003-1520-6127</orcidid><orcidid>https://orcid.org/0000-0002-4315-6043</orcidid><orcidid>https://orcid.org/0009-0000-9765-6222</orcidid><orcidid>https://orcid.org/0000-0002-1959-326X</orcidid><orcidid>https://orcid.org/0000-0001-5478-9340</orcidid></search><sort><creationdate>20210101</creationdate><title>Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression</title><author>Ouadid-Ahidouch, Halima ; Morjani, Hamid ; Schnipper, Julie ; Girault, Alban ; Ahidouch, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h320t-d4c7a6c86e18d5bdf50054a22d46f65af6adfdc0fa202c493161e64d9e989d3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ATP</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biological Physics</topic><topic>Biophysics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms</topic><topic>Cancer</topic><topic>Cell Behavior</topic><topic>Cellular Biology</topic><topic>Collagen 1</topic><topic>EGF</topic><topic>Engineering Sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Ion Channels</topic><topic>Life Sciences</topic><topic>Optics</topic><topic>Photonic</topic><topic>Physics</topic><topic>Signal and Image processing</topic><topic>Signal Transduction</topic><topic>Subcellular Processes</topic><topic>TGF-β</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ouadid-Ahidouch, Halima</creatorcontrib><creatorcontrib>Morjani, Hamid</creatorcontrib><creatorcontrib>Schnipper, Julie</creatorcontrib><creatorcontrib>Girault, Alban</creatorcontrib><creatorcontrib>Ahidouch, Ahmed</creatorcontrib><collection>ProQuest Ebook Central - Book Chapters - Demo use only</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Reviews of physiology, biochemistry and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ouadid-Ahidouch, Halima</au><au>Morjani, Hamid</au><au>Schnipper, Julie</au><au>Girault, Alban</au><au>Ahidouch, Ahmed</au><au>Pardo, Luis A</au><au>Stock, Christian</au><au>Pardo, Luis A.</au><au>Stock, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression</atitle><jtitle>Reviews of physiology, biochemistry and pharmacology</jtitle><addtitle>Rev Physiol Biochem Pharmacol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>181</volume><spage>1</spage><epage>38</epage><pages>1-38</pages><issn>0303-4240</issn><issn>1386-1425</issn><eissn>1617-5786</eissn><eissn>1873-3557</eissn><isbn>3030909190</isbn><isbn>9783030909192</isbn><eisbn>9783030909208</eisbn><eisbn>3030909204</eisbn><abstract>In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer.</abstract><cop>Switzerland</cop><pub>Springer International Publishing AG</pub><pmid>32761457</pmid><doi>10.1007/112_2020_19</doi><oclcid>1290724329</oclcid><tpages>38</tpages><orcidid>https://orcid.org/0000-0001-7869-5242</orcidid><orcidid>https://orcid.org/0000-0003-1959-7807</orcidid><orcidid>https://orcid.org/0000-0002-1100-8759</orcidid><orcidid>https://orcid.org/0000-0003-1520-6127</orcidid><orcidid>https://orcid.org/0000-0002-4315-6043</orcidid><orcidid>https://orcid.org/0009-0000-9765-6222</orcidid><orcidid>https://orcid.org/0000-0002-1959-326X</orcidid><orcidid>https://orcid.org/0000-0001-5478-9340</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-4240 |
| ispartof | Reviews of physiology, biochemistry and pharmacology, 2021-01, Vol.181, p.1-38 |
| issn | 0303-4240 1386-1425 1617-5786 1873-3557 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03164510v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ATP Biochemistry, Molecular Biology Biological Physics Biophysics Breast cancer Breast Neoplasms Cancer Cell Behavior Cellular Biology Collagen 1 EGF Engineering Sciences Female Humans Hypoxia Ion Channels Life Sciences Optics Photonic Physics Signal and Image processing Signal Transduction Subcellular Processes TGF-β Transforming Growth Factor beta - metabolism Tumor Microenvironment |
| title | Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A06%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20the%20Tumor%20Environment%20on%20Ion%20Channels:%20Implication%20for%20Breast%20Cancer%20Progression&rft.jtitle=Reviews%20of%20physiology,%20biochemistry%20and%20pharmacology&rft.au=Ouadid-Ahidouch,%20Halima&rft.date=2021-01-01&rft.volume=181&rft.spage=1&rft.epage=38&rft.pages=1-38&rft.issn=0303-4240&rft.eissn=1617-5786&rft.isbn=3030909190&rft.isbn_list=9783030909192&rft_id=info:doi/10.1007/112_2020_19&rft_dat=%3Cproquest_hal_p%3EEBC6838857_5_9%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&rft.eisbn=9783030909208&rft.eisbn_list=3030909204&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=EBC6838857_5_9&rft_id=info:pmid/32761457&rfr_iscdi=true |