Effects of physical activity on cell‐to‐cell communication during type 2 diabetes: A focus on miRNA signaling
Type 2 diabetes (TD2) is a progressive disease characterized by hyperglycemia that results from alteration in insulin secretion, insulin resistance, or both. A number of alterations involving different tissues and organs have been reported to the development and the progression of T2D, and more rele...
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| Veröffentlicht in: | Fundamental & clinical pharmacology 2021-10, Vol.35 (5), p.808-821 |
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| description | Type 2 diabetes (TD2) is a progressive disease characterized by hyperglycemia that results from alteration in insulin secretion, insulin resistance, or both. A number of alterations involving different tissues and organs have been reported to the development and the progression of T2D, and more relevantly, through cell‐to‐cell communication pathways. Recent studies demonstrated that miRNAs are considerably implicated to cell‐to‐cell communication during T2D. Physical activity (PA) is associated with decreasing risks of developing T2D and acts as insulin‐like factor. Cumulative evidence suggests that this effect could be mediated in part through improving insulin sensitivity in T2D and obese patients and modulating miRNAs synthesis and release in healthy patients. Therefore, the practice of PA should ideally be established before the initiation of T2D. This review describes cell‐to‐cell communications involved in the pathophysiology of T2D during PA. |
| doi_str_mv | 10.1111/fcp.12665 |
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A number of alterations involving different tissues and organs have been reported to the development and the progression of T2D, and more relevantly, through cell‐to‐cell communication pathways. Recent studies demonstrated that miRNAs are considerably implicated to cell‐to‐cell communication during T2D. Physical activity (PA) is associated with decreasing risks of developing T2D and acts as insulin‐like factor. Cumulative evidence suggests that this effect could be mediated in part through improving insulin sensitivity in T2D and obese patients and modulating miRNAs synthesis and release in healthy patients. Therefore, the practice of PA should ideally be established before the initiation of T2D. 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A number of alterations involving different tissues and organs have been reported to the development and the progression of T2D, and more relevantly, through cell‐to‐cell communication pathways. Recent studies demonstrated that miRNAs are considerably implicated to cell‐to‐cell communication during T2D. Physical activity (PA) is associated with decreasing risks of developing T2D and acts as insulin‐like factor. Cumulative evidence suggests that this effect could be mediated in part through improving insulin sensitivity in T2D and obese patients and modulating miRNAs synthesis and release in healthy patients. Therefore, the practice of PA should ideally be established before the initiation of T2D. This review describes cell‐to‐cell communications involved in the pathophysiology of T2D during PA.</description><subject>antidiabetic drugs</subject><subject>Cell Behavior</subject><subject>Cell interactions</subject><subject>Cellular Biology</subject><subject>Communication</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Endocrinology and metabolism</subject><subject>Exercise</subject><subject>extracellular vesicles</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Life Sciences</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Organs</subject><subject>Pharmacology</subject><subject>Physical activity</subject><subject>Risk reduction</subject><subject>Signal Transduction</subject><subject>type 2 diabetes</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURi0EokNhwQsgS2zKIq2v_-KwG41aijQChGBtOY7dukriNE6KsuMReEaeBIcpRULCC_vaPvrsq4PQSyCnkMeZt8MpUCnFI7QBXtJCUSIfow0pZVmwSsERepbSDSFQEpBP0RFjshSkIht0e-69s1PC0ePheknBmhYbO4W7MC049ti6tv35_ccU87TW2Maum_vMTSFfN_MY-is8LYPDFDfB1G5y6S3eYh_tnNaELnz-sMUpXPWmzexz9MSbNrkX9-sx-npx_mV3Wew_vnu_2-4LyykVReWlKAG8kxaIZI2xyjrOZV0pQUHaummYKRUHo_K2EowZIn3twDHhjBLsGL055F6bVg9j6My46GiCvtzu9XpGGEjgStxBZk8O7DDG29mlSXchrd2a3sU5acorxZUUwDP6-h_0Js5jbi1ToqSCkmzk7-N2jCmNzj_8AIhenensTP92ltlX94lz3bnmgfwjKQNnB-BbaN3y_yR9sft0iPwF-IGgRw</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Foudi, Nabil</creator><creator>Legeay, Samuel</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-5393-995X</orcidid><orcidid>https://orcid.org/0000-0002-1616-2210</orcidid></search><sort><creationdate>202110</creationdate><title>Effects of physical activity on cell‐to‐cell communication during type 2 diabetes: A focus on miRNA signaling</title><author>Foudi, Nabil ; 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A number of alterations involving different tissues and organs have been reported to the development and the progression of T2D, and more relevantly, through cell‐to‐cell communication pathways. Recent studies demonstrated that miRNAs are considerably implicated to cell‐to‐cell communication during T2D. Physical activity (PA) is associated with decreasing risks of developing T2D and acts as insulin‐like factor. Cumulative evidence suggests that this effect could be mediated in part through improving insulin sensitivity in T2D and obese patients and modulating miRNAs synthesis and release in healthy patients. Therefore, the practice of PA should ideally be established before the initiation of T2D. 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| subjects | antidiabetic drugs Cell Behavior Cell interactions Cellular Biology Communication Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Endocrinology and metabolism Exercise extracellular vesicles Human health and pathology Humans Hyperglycemia Insulin Insulin resistance Insulin secretion Life Sciences MicroRNAs - metabolism miRNA Organs Pharmacology Physical activity Risk reduction Signal Transduction type 2 diabetes |
| title | Effects of physical activity on cell‐to‐cell communication during type 2 diabetes: A focus on miRNA signaling |
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