The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

S 47445 is a positive modulator of glutamate AMPA-type receptors, possessing neurotrophic and enhancing synaptic plasticity effects as well as pro-cognitive and anti-stress properties. Here, the drug was assessed in the perinatal stress (PRS) rat model, known to have a high predictive validity with...

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Veröffentlicht in:	Neuropharmacology 2018-06, Vol.135, p.284-296
Hauptverfasser:	Morley-Fletcher, S., Zuena, A.R., Mairesse, J., Gatta, E., Van Camp, G., Bouwalerh, H., Riozzi, B., Battaglia, G., Pittaluga, A., Olivero, G., Mocaer, E., Bretin, S., Nicoletti, F., Maccari, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPAR-PAMs Animals Benzoxazines - pharmacology Chemical Sciences Cognition - drug effects Early life programming Emotions - drug effects Female Glutamate transmission Glutamic Acid - metabolism Hippocampus - metabolism Human health and pathology Life Sciences Male Nerve Tissue Proteins - metabolism or physical chemistry Pediatrics Preclinical model Predictive validity Pregnancy Prenatal Exposure Delayed Effects - prevention & control Rats Receptor, Metabotropic Glutamate 5 - metabolism Receptors, Glucocorticoid - metabolism Receptors, Oxytocin - metabolism Stress, Psychological - metabolism Stress-related disorders Theoretical and Triazines - pharmacology
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