Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs...

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Veröffentlicht in:Immunogenetics (New York) 2020-02, Vol.72 (1-2), p.25-36
Hauptverfasser: de Groot, Natasja G., Otting, Nel, Maccari, Giuseppe, Robinson, James, Hammond, John A., Blancher, Antoine, Lafont, Bernard A. P., Guethlein, Lisbeth A., Wroblewski, Emily E., Marsh, Steven G. E., Shiina, Takashi, Walter, Lutz, Vigilant, Linda, Parham, Peter, O’Connor, David H., Bontrop, Ronald E.
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container_title Immunogenetics (New York)
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creator de Groot, Natasja G.
Otting, Nel
Maccari, Giuseppe
Robinson, James
Hammond, John A.
Blancher, Antoine
Lafont, Bernard A. P.
Guethlein, Lisbeth A.
Wroblewski, Emily E.
Marsh, Steven G. E.
Shiina, Takashi
Walter, Lutz
Vigilant, Linda
Parham, Peter
O’Connor, David H.
Bontrop, Ronald E.
description The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.
doi_str_mv 10.1007/s00251-019-01132-x
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P. ; Guethlein, Lisbeth A. ; Wroblewski, Emily E. ; Marsh, Steven G. 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subjects Adaptive immunity
Alleles
Allergology
Animals
Apes
Biological evolution
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cercopithecidae - genetics
Conservation biology
Copy number
databases and bioinformatics in Immunogenetics
Databases, Genetic
Evolutionary conservation
Gene Function
Gene polymorphism
Genetics & Heredity
Hominidae - genetics
Human Genetics
Human health and pathology
Immune response
Immunology
Infectious diseases
Life Sciences
Life Sciences & Biomedicine
Major histocompatibility complex
Major Histocompatibility Complex - genetics
Major Histocompatibility Complex - physiology
Monkeys
Nomenclature
Phylogeny
Platyrrhini - genetics
Polymorphism
Polymorphism, Genetic
Primates
Primates - genetics
Primates - immunology
Review
Science & Technology
Terminology as Topic
Vertebrates
title Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species
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