Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cel...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2020-03, Vol.43 (3), p.130-132
Hauptverfasser: Meixiong, James, Basso, Lilian, Dong, Xinzhong, Gaudenzio, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Human health and pathology
Infectious diseases
Life Sciences
mast cell
MrgprB2/X2, skin
Nociceptive sensory neuron
substance P
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Zusammenfassung:Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2020.01.001