Prognostic value of pulse pressure after an acute coronary syndrome
Pulse pressure (PP) is a surrogate of aortic stiffness (AS) easily obtainable. The link between AS and cardio-vascular disease is documented, however, data regarding acute coronary syndrome (ACS) patients are scarce and contradictory. We aimed to assess the prognostic value of PP measured at admissi...
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| creator | Harbaoui, Brahim Nanchen, David Lantelme, Pierre Gencer, Baris Heg, Dick Klingenberg, Roland Räber, Lorenz Carballo, David Matter, Christian M. Windecker, Stephan Mach, François Rodondi, Nicolas Eeckhout, Eric Monney, Pierre Antiochos, Panagiotis Schwitter, Juerg Pascale, Patrizio Fournier, Stephane Courand, Pierre-Yves Lüscher, Thomas F. Muller, Olivier |
| description | Pulse pressure (PP) is a surrogate of aortic stiffness (AS) easily obtainable. The link between AS and cardio-vascular disease is documented, however, data regarding acute coronary syndrome (ACS) patients are scarce and contradictory. We aimed to assess the prognostic value of PP measured at admission, with regard to major adverse outcomes (all-cause mortality, recurrence of MI, and stroke), during the first year following an acute coronary syndrome (ACS).
The SPUM–ACS project is a prospective cohort study of patients with ACS conducted in 4 Swiss University hospitals. Patients with no PP at admission or with severe clinical heart failure or cardiogenic shock were excluded. Cox regression analyses were performed to determine associations between PP and outcomes (all-cause mortality, recurrence of myocardial infarction (MI), and stroke). Three multivariate Cox regression models were adjusted for hemodynamic, cardiovascular, and non-cardiovascular confounders, added successively.
Of 5635 eligible patients, 5070 met the inclusion criteria. Mean patient age was 63 years (range: 54–72), 79.6% were male, and mean blood pressure and PP were 93.9 ± 15.6 and 54 ± 17 mmHg, respectively. Multivariate analyses confirmed the prognostic significance of PP for each 10-mmHg increase for the composite endpoint, hazard ratio (HR) 1.126 [1.051–1.206], p = 0.001; all-cause mortality, HR1.129 [1.013–1.260], p = 0.029; and recurrence of MI, HR1.206 [1.102–1.320], p |
| doi_str_mv | 10.1016/j.atherosclerosis.2018.07.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03149103v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915018312097</els_id><sourcerecordid>2074136103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-ba198d6bbb9a1c5b338b0b3db9f163aa7e81abe5c84bb439697a9d23579f9a873</originalsourceid><addsrcrecordid>eNqNkMFu1DAQhi0EokvhFZAvSHBImImzsX3gUK1oi7RSOcDZsp0J9SobL3ayUt--Xm3bAyd8sCXr--cffYx9QqgRsPu6q-18TylmP57ukOsGUNUga0Dxiq1QSV1hq9rXbAXQYKVxDRfsXc47AGglqrfsQgCIctSKbX6m-GeKeQ6eH-24EI8DPyxjJn5IlPOSiNthpsTtxK1fZuI-pjjZ9MDzw9SnuKf37M1gS-LD03vJfl9__7W5rbZ3Nz82V9vKt42YK2dRq75zzmmLfu1KvwMneqcH7IS1khRaR2uvWudaoTstre4bsZZ60FZJccm-nOfe29EcUtiXJUy0wdxebc3pDwS2GkEcsbCfz-whxb8L5dnsQ_Y0jnaiuGTTgGxRdAUu6Lcz6ovPnGh4mY1gTs7Nzvzj3JycG5CmOC_5j09Vi9tT_5J-llyAmzNARc4xUDLZB5o89SGRn00fw39WPQLLjJyQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2074136103</pqid></control><display><type>article</type><title>Prognostic value of pulse pressure after an acute coronary syndrome</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Harbaoui, Brahim ; Nanchen, David ; Lantelme, Pierre ; Gencer, Baris ; Heg, Dick ; Klingenberg, Roland ; Räber, Lorenz ; Carballo, David ; Matter, Christian M. ; Windecker, Stephan ; Mach, François ; Rodondi, Nicolas ; Eeckhout, Eric ; Monney, Pierre ; Antiochos, Panagiotis ; Schwitter, Juerg ; Pascale, Patrizio ; Fournier, Stephane ; Courand, Pierre-Yves ; Lüscher, Thomas F. ; Muller, Olivier</creator><creatorcontrib>Harbaoui, Brahim ; Nanchen, David ; Lantelme, Pierre ; Gencer, Baris ; Heg, Dick ; Klingenberg, Roland ; Räber, Lorenz ; Carballo, David ; Matter, Christian M. ; Windecker, Stephan ; Mach, François ; Rodondi, Nicolas ; Eeckhout, Eric ; Monney, Pierre ; Antiochos, Panagiotis ; Schwitter, Juerg ; Pascale, Patrizio ; Fournier, Stephane ; Courand, Pierre-Yves ; Lüscher, Thomas F. ; Muller, Olivier</creatorcontrib><description>Pulse pressure (PP) is a surrogate of aortic stiffness (AS) easily obtainable. The link between AS and cardio-vascular disease is documented, however, data regarding acute coronary syndrome (ACS) patients are scarce and contradictory. We aimed to assess the prognostic value of PP measured at admission, with regard to major adverse outcomes (all-cause mortality, recurrence of MI, and stroke), during the first year following an acute coronary syndrome (ACS).
The SPUM–ACS project is a prospective cohort study of patients with ACS conducted in 4 Swiss University hospitals. Patients with no PP at admission or with severe clinical heart failure or cardiogenic shock were excluded. Cox regression analyses were performed to determine associations between PP and outcomes (all-cause mortality, recurrence of myocardial infarction (MI), and stroke). Three multivariate Cox regression models were adjusted for hemodynamic, cardiovascular, and non-cardiovascular confounders, added successively.
Of 5635 eligible patients, 5070 met the inclusion criteria. Mean patient age was 63 years (range: 54–72), 79.6% were male, and mean blood pressure and PP were 93.9 ± 15.6 and 54 ± 17 mmHg, respectively. Multivariate analyses confirmed the prognostic significance of PP for each 10-mmHg increase for the composite endpoint, hazard ratio (HR) 1.126 [1.051–1.206], p = 0.001; all-cause mortality, HR1.129 [1.013–1.260], p = 0.029; and recurrence of MI, HR1.206 [1.102–1.320], p < 0.001; but not for stroke, HR1.014[0.853–1.205].
PP measured at admission is a strong, independent prognostic marker predicting mortality and recurrence of MI after ACS. PP should be considered for the management of secondary prevention.
•Pulse pressure (PP), a surrogate of aortic stiffness, is associated with cardiovascular disease in various populations.•After an acute coronary syndrome (ACS), patients may exhibit a poor outcome despite a modern guideline-based management.•PP measured at admission is a robust and independent prognostic marker after diagnosis of ACS.•PP measurement could be critical to the development of new preventive strategies.•PP measurement could be critical to optimize the use of existing ones.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2018.07.013</identifier><identifier>PMID: 30033338</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acute coronary syndrome ; Acute Coronary Syndrome - diagnosis ; Acute Coronary Syndrome - mortality ; Acute Coronary Syndrome - physiopathology ; Acute Coronary Syndrome - therapy ; Aged ; Aortic stiffness ; Blood Pressure ; Cardiovascular events ; Cause of Death ; Female ; Humans ; Life Sciences ; Male ; Middle Aged ; Myocardial Infarction - diagnosis ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Patient Admission ; Predictive Value of Tests ; Prognosis ; Progression-Free Survival ; Prospective Studies ; Pulse pressure ; Recurrence ; Registries ; Risk Assessment ; Risk Factors ; Stroke - mortality ; Stroke - physiopathology ; Switzerland ; Time Factors ; Vascular Stiffness</subject><ispartof>Atherosclerosis, 2018-10, Vol.277, p.219-226</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-ba198d6bbb9a1c5b338b0b3db9f163aa7e81abe5c84bb439697a9d23579f9a873</citedby><cites>FETCH-LOGICAL-c423t-ba198d6bbb9a1c5b338b0b3db9f163aa7e81abe5c84bb439697a9d23579f9a873</cites><orcidid>0000-0001-8466-7360 ; 0000-0002-2493-3505 ; 0000-0003-0400-6234 ; 0000-0001-5259-1613 ; 0000-0003-2653-6762 ; 0000-0003-3199-7977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2018.07.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30033338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03149103$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Harbaoui, Brahim</creatorcontrib><creatorcontrib>Nanchen, David</creatorcontrib><creatorcontrib>Lantelme, Pierre</creatorcontrib><creatorcontrib>Gencer, Baris</creatorcontrib><creatorcontrib>Heg, Dick</creatorcontrib><creatorcontrib>Klingenberg, Roland</creatorcontrib><creatorcontrib>Räber, Lorenz</creatorcontrib><creatorcontrib>Carballo, David</creatorcontrib><creatorcontrib>Matter, Christian M.</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><creatorcontrib>Mach, François</creatorcontrib><creatorcontrib>Rodondi, Nicolas</creatorcontrib><creatorcontrib>Eeckhout, Eric</creatorcontrib><creatorcontrib>Monney, Pierre</creatorcontrib><creatorcontrib>Antiochos, Panagiotis</creatorcontrib><creatorcontrib>Schwitter, Juerg</creatorcontrib><creatorcontrib>Pascale, Patrizio</creatorcontrib><creatorcontrib>Fournier, Stephane</creatorcontrib><creatorcontrib>Courand, Pierre-Yves</creatorcontrib><creatorcontrib>Lüscher, Thomas F.</creatorcontrib><creatorcontrib>Muller, Olivier</creatorcontrib><title>Prognostic value of pulse pressure after an acute coronary syndrome</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Pulse pressure (PP) is a surrogate of aortic stiffness (AS) easily obtainable. The link between AS and cardio-vascular disease is documented, however, data regarding acute coronary syndrome (ACS) patients are scarce and contradictory. We aimed to assess the prognostic value of PP measured at admission, with regard to major adverse outcomes (all-cause mortality, recurrence of MI, and stroke), during the first year following an acute coronary syndrome (ACS).
The SPUM–ACS project is a prospective cohort study of patients with ACS conducted in 4 Swiss University hospitals. Patients with no PP at admission or with severe clinical heart failure or cardiogenic shock were excluded. Cox regression analyses were performed to determine associations between PP and outcomes (all-cause mortality, recurrence of myocardial infarction (MI), and stroke). Three multivariate Cox regression models were adjusted for hemodynamic, cardiovascular, and non-cardiovascular confounders, added successively.
Of 5635 eligible patients, 5070 met the inclusion criteria. Mean patient age was 63 years (range: 54–72), 79.6% were male, and mean blood pressure and PP were 93.9 ± 15.6 and 54 ± 17 mmHg, respectively. Multivariate analyses confirmed the prognostic significance of PP for each 10-mmHg increase for the composite endpoint, hazard ratio (HR) 1.126 [1.051–1.206], p = 0.001; all-cause mortality, HR1.129 [1.013–1.260], p = 0.029; and recurrence of MI, HR1.206 [1.102–1.320], p < 0.001; but not for stroke, HR1.014[0.853–1.205].
PP measured at admission is a strong, independent prognostic marker predicting mortality and recurrence of MI after ACS. PP should be considered for the management of secondary prevention.
•Pulse pressure (PP), a surrogate of aortic stiffness, is associated with cardiovascular disease in various populations.•After an acute coronary syndrome (ACS), patients may exhibit a poor outcome despite a modern guideline-based management.•PP measured at admission is a robust and independent prognostic marker after diagnosis of ACS.•PP measurement could be critical to the development of new preventive strategies.•PP measurement could be critical to optimize the use of existing ones.</description><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute Coronary Syndrome - mortality</subject><subject>Acute Coronary Syndrome - physiopathology</subject><subject>Acute Coronary Syndrome - therapy</subject><subject>Aged</subject><subject>Aortic stiffness</subject><subject>Blood Pressure</subject><subject>Cardiovascular events</subject><subject>Cause of Death</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Patient Admission</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Progression-Free Survival</subject><subject>Prospective Studies</subject><subject>Pulse pressure</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Stroke - mortality</subject><subject>Stroke - physiopathology</subject><subject>Switzerland</subject><subject>Time Factors</subject><subject>Vascular Stiffness</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EokvhFZAvSHBImImzsX3gUK1oi7RSOcDZsp0J9SobL3ayUt--Xm3bAyd8sCXr--cffYx9QqgRsPu6q-18TylmP57ukOsGUNUga0Dxiq1QSV1hq9rXbAXQYKVxDRfsXc47AGglqrfsQgCIctSKbX6m-GeKeQ6eH-24EI8DPyxjJn5IlPOSiNthpsTtxK1fZuI-pjjZ9MDzw9SnuKf37M1gS-LD03vJfl9__7W5rbZ3Nz82V9vKt42YK2dRq75zzmmLfu1KvwMneqcH7IS1khRaR2uvWudaoTstre4bsZZ60FZJccm-nOfe29EcUtiXJUy0wdxebc3pDwS2GkEcsbCfz-whxb8L5dnsQ_Y0jnaiuGTTgGxRdAUu6Lcz6ovPnGh4mY1gTs7Nzvzj3JycG5CmOC_5j09Vi9tT_5J-llyAmzNARc4xUDLZB5o89SGRn00fw39WPQLLjJyQ</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Harbaoui, Brahim</creator><creator>Nanchen, David</creator><creator>Lantelme, Pierre</creator><creator>Gencer, Baris</creator><creator>Heg, Dick</creator><creator>Klingenberg, Roland</creator><creator>Räber, Lorenz</creator><creator>Carballo, David</creator><creator>Matter, Christian M.</creator><creator>Windecker, Stephan</creator><creator>Mach, François</creator><creator>Rodondi, Nicolas</creator><creator>Eeckhout, Eric</creator><creator>Monney, Pierre</creator><creator>Antiochos, Panagiotis</creator><creator>Schwitter, Juerg</creator><creator>Pascale, Patrizio</creator><creator>Fournier, Stephane</creator><creator>Courand, Pierre-Yves</creator><creator>Lüscher, Thomas F.</creator><creator>Muller, Olivier</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8466-7360</orcidid><orcidid>https://orcid.org/0000-0002-2493-3505</orcidid><orcidid>https://orcid.org/0000-0003-0400-6234</orcidid><orcidid>https://orcid.org/0000-0001-5259-1613</orcidid><orcidid>https://orcid.org/0000-0003-2653-6762</orcidid><orcidid>https://orcid.org/0000-0003-3199-7977</orcidid></search><sort><creationdate>201810</creationdate><title>Prognostic value of pulse pressure after an acute coronary syndrome</title><author>Harbaoui, Brahim ; Nanchen, David ; Lantelme, Pierre ; Gencer, Baris ; Heg, Dick ; Klingenberg, Roland ; Räber, Lorenz ; Carballo, David ; Matter, Christian M. ; Windecker, Stephan ; Mach, François ; Rodondi, Nicolas ; Eeckhout, Eric ; Monney, Pierre ; Antiochos, Panagiotis ; Schwitter, Juerg ; Pascale, Patrizio ; Fournier, Stephane ; Courand, Pierre-Yves ; Lüscher, Thomas F. ; Muller, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-ba198d6bbb9a1c5b338b0b3db9f163aa7e81abe5c84bb439697a9d23579f9a873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute Coronary Syndrome - mortality</topic><topic>Acute Coronary Syndrome - physiopathology</topic><topic>Acute Coronary Syndrome - therapy</topic><topic>Aged</topic><topic>Aortic stiffness</topic><topic>Blood Pressure</topic><topic>Cardiovascular events</topic><topic>Cause of Death</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Patient Admission</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Progression-Free Survival</topic><topic>Prospective Studies</topic><topic>Pulse pressure</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Stroke - mortality</topic><topic>Stroke - physiopathology</topic><topic>Switzerland</topic><topic>Time Factors</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harbaoui, Brahim</creatorcontrib><creatorcontrib>Nanchen, David</creatorcontrib><creatorcontrib>Lantelme, Pierre</creatorcontrib><creatorcontrib>Gencer, Baris</creatorcontrib><creatorcontrib>Heg, Dick</creatorcontrib><creatorcontrib>Klingenberg, Roland</creatorcontrib><creatorcontrib>Räber, Lorenz</creatorcontrib><creatorcontrib>Carballo, David</creatorcontrib><creatorcontrib>Matter, Christian M.</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><creatorcontrib>Mach, François</creatorcontrib><creatorcontrib>Rodondi, Nicolas</creatorcontrib><creatorcontrib>Eeckhout, Eric</creatorcontrib><creatorcontrib>Monney, Pierre</creatorcontrib><creatorcontrib>Antiochos, Panagiotis</creatorcontrib><creatorcontrib>Schwitter, Juerg</creatorcontrib><creatorcontrib>Pascale, Patrizio</creatorcontrib><creatorcontrib>Fournier, Stephane</creatorcontrib><creatorcontrib>Courand, Pierre-Yves</creatorcontrib><creatorcontrib>Lüscher, Thomas F.</creatorcontrib><creatorcontrib>Muller, Olivier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harbaoui, Brahim</au><au>Nanchen, David</au><au>Lantelme, Pierre</au><au>Gencer, Baris</au><au>Heg, Dick</au><au>Klingenberg, Roland</au><au>Räber, Lorenz</au><au>Carballo, David</au><au>Matter, Christian M.</au><au>Windecker, Stephan</au><au>Mach, François</au><au>Rodondi, Nicolas</au><au>Eeckhout, Eric</au><au>Monney, Pierre</au><au>Antiochos, Panagiotis</au><au>Schwitter, Juerg</au><au>Pascale, Patrizio</au><au>Fournier, Stephane</au><au>Courand, Pierre-Yves</au><au>Lüscher, Thomas F.</au><au>Muller, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of pulse pressure after an acute coronary syndrome</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2018-10</date><risdate>2018</risdate><volume>277</volume><spage>219</spage><epage>226</epage><pages>219-226</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Pulse pressure (PP) is a surrogate of aortic stiffness (AS) easily obtainable. The link between AS and cardio-vascular disease is documented, however, data regarding acute coronary syndrome (ACS) patients are scarce and contradictory. We aimed to assess the prognostic value of PP measured at admission, with regard to major adverse outcomes (all-cause mortality, recurrence of MI, and stroke), during the first year following an acute coronary syndrome (ACS).
The SPUM–ACS project is a prospective cohort study of patients with ACS conducted in 4 Swiss University hospitals. Patients with no PP at admission or with severe clinical heart failure or cardiogenic shock were excluded. Cox regression analyses were performed to determine associations between PP and outcomes (all-cause mortality, recurrence of myocardial infarction (MI), and stroke). Three multivariate Cox regression models were adjusted for hemodynamic, cardiovascular, and non-cardiovascular confounders, added successively.
Of 5635 eligible patients, 5070 met the inclusion criteria. Mean patient age was 63 years (range: 54–72), 79.6% were male, and mean blood pressure and PP were 93.9 ± 15.6 and 54 ± 17 mmHg, respectively. Multivariate analyses confirmed the prognostic significance of PP for each 10-mmHg increase for the composite endpoint, hazard ratio (HR) 1.126 [1.051–1.206], p = 0.001; all-cause mortality, HR1.129 [1.013–1.260], p = 0.029; and recurrence of MI, HR1.206 [1.102–1.320], p < 0.001; but not for stroke, HR1.014[0.853–1.205].
PP measured at admission is a strong, independent prognostic marker predicting mortality and recurrence of MI after ACS. PP should be considered for the management of secondary prevention.
•Pulse pressure (PP), a surrogate of aortic stiffness, is associated with cardiovascular disease in various populations.•After an acute coronary syndrome (ACS), patients may exhibit a poor outcome despite a modern guideline-based management.•PP measured at admission is a robust and independent prognostic marker after diagnosis of ACS.•PP measurement could be critical to the development of new preventive strategies.•PP measurement could be critical to optimize the use of existing ones.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30033338</pmid><doi>10.1016/j.atherosclerosis.2018.07.013</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8466-7360</orcidid><orcidid>https://orcid.org/0000-0002-2493-3505</orcidid><orcidid>https://orcid.org/0000-0003-0400-6234</orcidid><orcidid>https://orcid.org/0000-0001-5259-1613</orcidid><orcidid>https://orcid.org/0000-0003-2653-6762</orcidid><orcidid>https://orcid.org/0000-0003-3199-7977</orcidid></addata></record> |
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| subjects | Acute coronary syndrome Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - mortality Acute Coronary Syndrome - physiopathology Acute Coronary Syndrome - therapy Aged Aortic stiffness Blood Pressure Cardiovascular events Cause of Death Female Humans Life Sciences Male Middle Aged Myocardial Infarction - diagnosis Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocardial Infarction - therapy Patient Admission Predictive Value of Tests Prognosis Progression-Free Survival Prospective Studies Pulse pressure Recurrence Registries Risk Assessment Risk Factors Stroke - mortality Stroke - physiopathology Switzerland Time Factors Vascular Stiffness |
| title | Prognostic value of pulse pressure after an acute coronary syndrome |
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