Feasibility of, and critical paths for mycophenolate mofetil Bayesian dose adjustment: Pharmacological re-appraisal of a concentration-controlled versus fixed-dose trial in renal transplant recipients

The aim of this study was to analyze retrospectively and critically the different steps of the individual dose adjustment procedure employed in the concentration-controlled (CC) versus fixed-dose trial Apomygre, which showed that mycophenolate mofetil (MMF) dose adjustment using a limited sampling s...

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Veröffentlicht in:	Pharmacological research 2010-02, Vol.61 (2), p.167-174
Hauptverfasser:	Prémaud, A., Rousseau, A., Le Meur, Y., Venisse, N., Loichot, C., Turcant, A., Hoizey, G., Compagnon, P., Hary, L., Debruyne, D., Saivin, S., Jacqz-Aigrain, E., Marquet, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Area Under Curve Bayes Theorem Bayesian dose adjustment Concentration-controlled versus fixed-dose trial Dose-Response Relationship, Drug Drug Dosage Calculations Drug Monitoring - methods Feasibility Studies France Graft Rejection - etiology Graft Rejection - prevention & control Graft Survival - drug effects Guideline Adherence Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Kidney Transplantation - adverse effects Life Sciences Linear Models Mycophenolate mofetil Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - blood Practice Guidelines as Topic Practice Patterns, Physicians Randomized Controlled Trials as Topic Renal transplantation Retrospective Studies Time Factors Treatment Outcome
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