Poor Performance of Rapid Molecular Tests to Define Eligibility for the Shortcourse Multidrug-resistant Tuberculosis Regimen

Poor Performance of Rapid Molecular Tests to Define Eligibility for the Shortcourse Multidrug-resistant Tuberculosis Regimen

The World Health Organization recommends shortcourse regimen (SCR) to treat multidrug resistant tuberculosis for patients with strains susceptible by line-probe assays (LPAs) to second-line drugs. Our retrospective study shows LPAs have suboptimal specificity in predicting eligibility for SCR; a qua...

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Veröffentlicht in:Clinical infectious diseases 2019-04, Vol.68 (8), p.1410-1412
Hauptverfasser: Guglielmetti, Lorenzo, Sougakoff, Wladimir, Maitre, Thomas, Brossier, Florence, Jarlier, Vincent, Robert, Jérôme, Veziris, Nicolas, Aubry, Alexandra
Format: Artikel
Sprache:eng
Schlagworte:
Bacteriology
BRIEF REPORTS
Life Sciences
Microbiology and Parasitology
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Zusammenfassung:The World Health Organization recommends shortcourse regimen (SCR) to treat multidrug resistant tuberculosis for patients with strains susceptible by line-probe assays (LPAs) to second-line drugs. Our retrospective study shows LPAs have suboptimal specificity in predicting eligibility for SCR; a quarter of eligible patients would receive inadequate therapy with SCR.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciy808