Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic AMP-dependent chloride channel that mediates electrolyte transport across the luminal surface of epithelial cells. In this paper, we describe the CFTR regulation by syntaxin 8, a t-SNARE protein (target soluble N-ethylmaleimi...

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Veröffentlicht in:	Journal of cell science 2004-04, Vol.117 (Pt 10), p.1923-1935
Hauptverfasser:	Bilan, Frédéric, Thoreau, Vincent, Nacfer, Magali, Dérand, Renaud, Norez, Caroline, Cantereau, Anne, Garcia, Martine, Becq, Frédéric, Kitzis, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, Surface - metabolism Biochemistry, Molecular Biology Cell Line CHO Cells COS Cells Cricetinae Cystic Fibrosis Transmembrane Conductance Regulator - metabolism DNA, Complementary - metabolism Electrophoresis, Polyacrylamide Gel Endosomes - metabolism Glutathione Transferase - metabolism Humans Immunoblotting Immunoprecipitation Iodides - chemistry Life Sciences Lysosomal Membrane Proteins Membrane Proteins - metabolism Membrane Proteins - physiology Microscopy, Confocal Microscopy, Fluorescence Nerve Tissue Proteins - metabolism Patch-Clamp Techniques Protein Binding Protein Transport Qa-SNARE Proteins rab GTP-Binding Proteins - metabolism Receptors, Transferrin - metabolism Signal Transduction Syntaxin 1 Time Factors Transfection
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