Ca 2+ allostery in PTH-receptor signaling

The parathyroid hormone (PTH) and its related peptide (PTHrP) activate PTH receptor (PTHR) signaling, but only the PTH sustains G -mediated adenosine 3',5'-cyclic monophosphate (cAMP) production after PTHR internalization into early endosomes. The mechanism of this unexpected behavior for...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-02, Vol.116 (8), p.3294-3299
Hauptverfasser:	White, Alex D, Fang, Fei, Jean-Alphonse, Frédéric G, Clark, Lisa J, An, Hyun-Jung, Liu, Hongda, Zhao, Yang, Reynolds, Shelley L, Lee, Sihoon, Xiao, Kunhong, Sutkeviciute, Ieva, Vilardaga, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - genetics Animals Biochemistry, Molecular Biology Calcium Signaling - genetics Cell Behavior Cellular Biology Chlorocebus aethiops COS Cells Cyclic AMP - genetics Cyclic AMP - metabolism Humans Hypocalcemia - genetics Hypocalcemia - metabolism Hypocalcemia - pathology Kinetics Life Sciences Ligands Molecular biology Molecular Networks Parathyroid Hormone - genetics Parathyroid Hormone - metabolism Parathyroid Hormone-Related Protein - genetics Pharmaceutical sciences Pharmacology Point Mutation - genetics Protein Binding - genetics Receptor, Parathyroid Hormone, Type 1 - genetics Receptor, Parathyroid Hormone, Type 1 - metabolism Reproductive Biology Sexual reproduction
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