Determination of the pharmacokinetic‐pharmacodynamic cut‐off values of marbofloxacin in horses to support the establishment of a clinical breakpoint for antimicrobial susceptibility testing

Background Marbofloxacin (MBX), a fluoroquinolone (FQ), is considered as a critical antibiotic requiring antimicrobial susceptibility testing (AST) for prudent use. No clinical breakpoint (CBP) currently exists to interpret the results of such tests in horses. Objectives To compute PK/PD cut‐offs (P...

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Veröffentlicht in:	Equine veterinary journal 2021-09, Vol.53 (5), p.1047-1055
Hauptverfasser:	Bousquet‐Mélou, Alain, Schneider, Marc, El Garch, Farid, Broussou, Diane C., Ferran, Aude A., Lallemand, Elodie A., Triboulloy, Cyrielle, Damborg, Peter, Toutain, Pierre‐Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial agents antimicrobial susceptibility testing horse Life Sciences monte carlo simulations Pathogens Pharmacodynamics Pharmacokinetics PK/PD cut‐off population pharmacokinetic
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