The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus
Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision me...
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| creator | Giacomelli, Roberto Afeltra, Antonella Bartoloni, Elena Berardicurti, Onorina Bombardieri, Michele Bortoluzzi, Alessandra Carubbi, Francesco Caso, Francesco Cervera, Ricard Ciccia, Francesco Cipriani, Paola Coloma-Bazán, Emmanuel Conti, Fabrizio Costa, Luisa D’Angelo, Salvatore Distler, Oliver Feist, Eugen Foulquier, Nathan Gabini, Marco Gerber, Vanessa Gerli, Roberto Grembiale, Rosa Daniela Guggino, Giuliana Hoxha, Ariela Iagnocco, Annamaria Jordan, Suzana Kahaleh, Bashar Lauper, Kim Liakouli, Vasiliki Lubrano, Ennio Margiotta, Domenico Naty, Saverio Navarini, Luca Perosa, Federico Perricone, Carlo Perricone, Roberto Prete, Marcella Pers, Jacques-Olivier Pitzalis, Costantino Priori, Roberta Rivellese, Felice Ruffatti, Amelia Ruscitti, Piero Scarpa, Raffaele Shoenfeld, Yehuda Triolo, Giovanni Tzioufas, Athanasios |
| description | Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure.
Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events.
In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients. |
| doi_str_mv | 10.1016/j.autrev.2020.102738 |
| format | Article |
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Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events.
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In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure.
Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events.
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In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure.
Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events.
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| identifier | ISSN: 1568-9972 |
| ispartof | Autoimmunity reviews, 2021-02, Vol.20 (2), p.102738, Article 102738 |
| issn | 1568-9972 1568-9972 1873-0183 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03098438v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | antiphospholipid syndrome Autoimmune Diseases - therapy Consensus Humans Immunology Life Sciences Lupus Erythematosus, Systemic Precision Medicine primary Sjogren’s syndrome rheumatoid arthritis Sjogren's Syndrome spondyloarthritides systemic lupus erythematosus systemic sclerosis |
| title | The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T20%3A45%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-hal_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20growing%20role%20of%20precision%20medicine%20for%20the%20treatment%20of%20autoimmune%20diseases;%20results%20of%20a%20systematic%20review%20of%20literature%20and%20Experts%E2%80%99%20Consensus&rft.jtitle=Autoimmunity%20reviews&rft.au=Giacomelli,%20Roberto&rft.date=2021-02-01&rft.volume=20&rft.issue=2&rft.spage=102738&rft.pages=102738-&rft.artnum=102738&rft.issn=1568-9972&rft.eissn=1568-9972&rft_id=info:doi/10.1016/j.autrev.2020.102738&rft_dat=%3Chal_cross%3Eoai_HAL_hal_03098438v1%3C/hal_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33326854&rft_els_id=S1568997220303190&rfr_iscdi=true |