Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins

Type-5 metabotropic glutamate receptors (mGlu5) have been implicated in the mechanism of resilience to stress. They form part of the postsynaptic density (PSD), a thickening of the glutamatergic synapse that acts as a multimodal hub for multiple cellular signaling. Perinatal stress in rats triggers...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2020-01, Vol.96, p.109725-109725, Article 109725
Hauptverfasser:	Buonaguro, Elisabetta F., Morley-Fletcher, Sara, Avagliano, Camilla, Vellucci, Licia, Iasevoli, Felice, Bouwalerh, Hammou, Van Camp, Gilles, Nicoletti, Ferdinando, Maccari, Stefania, de Bartolomeis, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Animals Brain - metabolism Chemical Sciences Early life programming Female Gene Expression Homer Scaffolding Proteins - biosynthesis Homer Scaffolding Proteins - genetics Life Sciences Male or physical chemistry Post-Synaptic Density - genetics Post-Synaptic Density - metabolism Pregnancy Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 - biosynthesis Receptor, Metabotropic Glutamate 5 - genetics Restraint, Physical Stress Stress, Psychological - metabolism Stress, Psychological - psychology Synapse Theoretical and
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