Modeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo

CADY is a cell-penetrating peptide spontaneously making non-covalent complexes with Short interfering RNAs (siRNAs) in water. Neither the structure of CADY nor that of the complexes is resolved. We have calculated and analyzed 3D models of CADY and of the non-covalent CADY–siRNA complexes in order t...

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Veröffentlicht in:	Biochimica et biophysica acta 2013-02, Vol.1828 (2), p.499-509
Hauptverfasser:	Crowet, Jean-Marc, Lins, Laurence, Deshayes, Sébastien, Divita, Gilles, Morris, May, Brasseur, Robert, Thomas, Annick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Arginine - chemistry Biochemistry, biophysics & molecular biology Biochemistry, Molecular Biology Biochimie, biophysique & biologie moléculaire CADY Cell penetrating peptide Cell-Penetrating Peptides - chemistry Genetic Vectors Hydrophobic and Hydrophilic Interactions Life Sciences Models, Molecular Molecular Conformation Molecular dynamics Molecular Dynamics Simulation Molecular modeling Non-covalent complex Peptides - chemistry Protein Binding Protein Structure, Secondary RNA, Small Interfering - metabolism Sciences du vivant siRNA Static Electricity Thermodynamics Time Factors
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