Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

In its unliganded form, the retinoic acid receptor (RAR) in heterodimer with the retinoid X receptor (RXR) exerts a strong repressive activity facilitated by the recruitment of transcriptional corepressors in the promoter region of target genes. By integrating complementary structural, biophysical,...

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Veröffentlicht in:	Structure (London) 2019-08, Vol.27 (8), p.1270-1285.e6
Hauptverfasser:	Cordeiro, Tiago N., Sibille, Nathalie, Germain, Pierre, Barthe, Philippe, Boulahtouf, Abdelhay, Allemand, Fréderic, Bailly, Rémy, Vivat, Valérie, Ebel, Christine, Barducci, Alessandro, Bourguet, William, le Maire, Albane, Bernadó, Pau
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Chlorocebus aethiops corepressor COS Cells dynamic protein complex Evolution, Molecular Gene Expression Regulation Humans integrative structural biology intrinsically disordered protein Life Sciences Models, Molecular Molecular Dynamics Simulation multivalent protein Nuclear Magnetic Resonance Nuclear Receptor Co-Repressor 1 - chemistry Nuclear Receptor Co-Repressor 1 - genetics Nuclear Receptor Co-Repressor 1 - metabolism Protein Domains Protein Folding Protein Multimerization Protein Structure, Secondary retinoic acid receptor Retinoic Acid Receptor alpha - chemistry Retinoic Acid Receptor alpha - metabolism Retinoid X Receptors - chemistry Retinoid X Receptors - metabolism small-angle X-ray scattering Structural Biology structural modeling transcriptional regulation
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