The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing

G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual inter...

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Veröffentlicht in:	Molecular cell 2014-01, Vol.53 (2), p.277-289
Hauptverfasser:	Mozzetta, Chiara, Pontis, Julien, Fritsch, Lauriane, Robin, Philippe, Portoso, Manuela, Proux, Caroline, Margueron, Raphaël, Ait-Si-Ali, Slimane
Format:	Artikel
Sprache:	eng
Schlagworte:	Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation Gene Silencing HeLa Cells Histocompatibility Antigens - metabolism Histocompatibility Antigens - physiology Histone-Lysine N-Methyltransferase - metabolism Histone-Lysine N-Methyltransferase - physiology Histones - metabolism Humans Life Sciences Methylation Polycomb Repressive Complex 2 - physiology Promoter Regions, Genetic
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