Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases
To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of...
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| Veröffentlicht in: | European journal of surgical oncology 2021-06, Vol.47 (6), p.1376-1383 |
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| creator | Giorgi, Roch Vergez, Sébastien Le Taillandier de Gabory, Ludovic Costes-Martineau, Valérie Herman, Philippe Mauvais, Olivier Malard, Olivier Garrel, Renaud Barry, Béatrix Bach, Christine Chevalier, Dominique Mouawad, Francois Merol, Jean-Claude Bastit, Vianney Thariat, Juliette Dufour, Xavier Righini, Christian-Adrien Moya-Plana, Antoine Radulesco, Thomas Michel, Justin Baujat, Bertrand Andry, G. Badet, J.-M. Badoual, C. Baglin, A.C. Banal, A. Baudin, E. Baujat, B. Bertolus, C. Bessède, J.-P. Blanchard, D. Bozorg-Grayeli, A. Breheret, R. Breton, P. Brugel, L. Calais, G. Casiraghi, O. Castillo, L. Ceruse, P. Chabolle, F. Choussy, O. Coste, A. Costes, V. Crampette, L. Darrouzet, V. Demez, P. Devauchelle, B. Dolivet, G. Dufour, X. Faivre, S. Fakhry, N. Ferron, C. Floret, F. Garrel, R. Geoffrois, L. Gilain, L. Giovanni, A. Girod, A. Hans, S. Hofman, P. Housset, M. Jankowski, R. Jegoux, F. Kaminsky, M.-C. Kolb, F. St Guily, J. Lacau Laccoureye, L. Lallemant, B. Lang, P. Lartigau, E. Lavieille, J.-P. Lefevre, M. Malard, O. Mauvais, O. Merol, J.-C. Michel, J. Morinière, S. Moulin, G. Poissonnet, G. Prades, J.-M. Radulesco, T. de Raucourt, D. Reyt, E. Righini, C. Robin, Y. Marie Rolland, F. Sarroul, N. Schultz, P. Sterkers, O. Strunski, V. Tassart, M. Testelin, S. Thariat, J. Timochenko, A. Toussaint, B. Van den Abbeele, T. Varoquaux, A. Veillon, F. Vergez, S. Wassef, M. |
| description | To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.
Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.
A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.
Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care. |
| doi_str_mv | 10.1016/j.ejso.2020.11.123 |
| format | Article |
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Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.
A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.
Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2020.11.123</identifier><identifier>PMID: 33248902</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alcohol Drinking - adverse effects ; Cancer ; Carcinoma, Mucoepidermoid - secondary ; Carcinoma, Mucoepidermoid - therapy ; Chemoradiotherapy, Adjuvant ; Databases, Factual ; Diabetes Complications - complications ; Disease-Free Survival ; Follow-Up Studies ; France ; Humans ; Life Sciences ; Lymphatic Metastasis ; Middle Aged ; Mucoepidermoid carcinoma ; Neck Dissection ; Neoplasm Grading ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Parotid gland ; Prospective Studies ; Radiotherapy, Adjuvant ; Salivary Gland Neoplasms - pathology ; Salivary Gland Neoplasms - therapy ; Salivary glands ; Survival Rate ; Young Adult</subject><ispartof>European journal of surgical oncology, 2021-06, Vol.47 (6), p.1376-1383</ispartof><rights>2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology</rights><rights>Copyright © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. 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Lacau</creatorcontrib><creatorcontrib>Laccoureye, L.</creatorcontrib><creatorcontrib>Lallemant, B.</creatorcontrib><creatorcontrib>Lang, P.</creatorcontrib><creatorcontrib>Lartigau, E.</creatorcontrib><creatorcontrib>Lavieille, J.-P.</creatorcontrib><creatorcontrib>Lefevre, M.</creatorcontrib><creatorcontrib>Malard, O.</creatorcontrib><creatorcontrib>Mauvais, O.</creatorcontrib><creatorcontrib>Merol, J.-C.</creatorcontrib><creatorcontrib>Michel, J.</creatorcontrib><creatorcontrib>Morinière, S.</creatorcontrib><creatorcontrib>Moulin, G.</creatorcontrib><creatorcontrib>Poissonnet, G.</creatorcontrib><creatorcontrib>Prades, J.-M.</creatorcontrib><creatorcontrib>Radulesco, T.</creatorcontrib><creatorcontrib>de Raucourt, D.</creatorcontrib><creatorcontrib>Reyt, E.</creatorcontrib><creatorcontrib>Righini, C.</creatorcontrib><creatorcontrib>Robin, Y. Marie</creatorcontrib><creatorcontrib>Rolland, F.</creatorcontrib><creatorcontrib>Sarroul, N.</creatorcontrib><creatorcontrib>Schultz, P.</creatorcontrib><creatorcontrib>Sterkers, O.</creatorcontrib><creatorcontrib>Strunski, V.</creatorcontrib><creatorcontrib>Tassart, M.</creatorcontrib><creatorcontrib>Testelin, S.</creatorcontrib><creatorcontrib>Thariat, J.</creatorcontrib><creatorcontrib>Timochenko, A.</creatorcontrib><creatorcontrib>Toussaint, B.</creatorcontrib><creatorcontrib>Van den Abbeele, T.</creatorcontrib><creatorcontrib>Varoquaux, A.</creatorcontrib><creatorcontrib>Veillon, F.</creatorcontrib><creatorcontrib>Vergez, S.</creatorcontrib><creatorcontrib>Wassef, M.</creatorcontrib><creatorcontrib>REFCOR members</creatorcontrib><title>Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.
Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.
A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.
Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Cancer</subject><subject>Carcinoma, Mucoepidermoid - secondary</subject><subject>Carcinoma, Mucoepidermoid - therapy</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Databases, Factual</subject><subject>Diabetes Complications - complications</subject><subject>Disease-Free Survival</subject><subject>Follow-Up Studies</subject><subject>France</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>Mucoepidermoid carcinoma</subject><subject>Neck Dissection</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Parotid gland</subject><subject>Prospective Studies</subject><subject>Radiotherapy, Adjuvant</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Gland Neoplasms - therapy</subject><subject>Salivary glands</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9PGzEQxa2qVQm0X6CHykc4bBiP92_VSxQRgpQWKaJny9iT4rAbp_ZuKq795HgVypGTpfFv3sy8x9gXAVMBorzcTmkb_RQBU0FMBcp3bCIKiRmKonrPJlDldVY1tTxhpzFuAaCRVfORnUiJed0ATti_H4PxtHeWQued5UYH43a-09xveNStO-jwxH-3emfjNz7ji0A788B_Uv_Xh8cRWutAfEna8sSkD_PI74bOh8jP11eL-e36gu-Dj3syvTsQj_1gn8Y-bDBNixQ_sQ8b3Ub6_PKesV-Lq7v5MlvdXt_MZ6vMFAB9ViFibfNGkyYUUMkKqdClKcFKMg2A2VS10QjS5oj3tbZ5IaUVwjTagi7kGbs46j7oVu2D69JlymunlrOVGmsgIW-gFAeR2PMjm1b_M1DsVeeioTb5QH6ICvOyqMoibZFQPKImXRkDbV61BagxJ7VVY05qzEkJoVJOqenri_5w35F9bfkfTAK-HwFKjhwcBRWNS9aTdSE5qax3b-k_A8DioiI</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Giorgi, Roch</creator><creator>Vergez, Sébastien</creator><creator>Le Taillandier de Gabory, Ludovic</creator><creator>Costes-Martineau, Valérie</creator><creator>Herman, Philippe</creator><creator>Mauvais, Olivier</creator><creator>Malard, Olivier</creator><creator>Garrel, Renaud</creator><creator>Barry, Béatrix</creator><creator>Bach, Christine</creator><creator>Chevalier, Dominique</creator><creator>Mouawad, Francois</creator><creator>Merol, Jean-Claude</creator><creator>Bastit, Vianney</creator><creator>Thariat, Juliette</creator><creator>Dufour, Xavier</creator><creator>Righini, Christian-Adrien</creator><creator>Moya-Plana, Antoine</creator><creator>Radulesco, Thomas</creator><creator>Michel, Justin</creator><creator>Baujat, Bertrand</creator><creator>Andry, G.</creator><creator>Badet, J.-M.</creator><creator>Badoual, C.</creator><creator>Baglin, A.C.</creator><creator>Banal, A.</creator><creator>Baudin, E.</creator><creator>Baujat, B.</creator><creator>Bertolus, C.</creator><creator>Bessède, J.-P.</creator><creator>Blanchard, D.</creator><creator>Bozorg-Grayeli, A.</creator><creator>Breheret, R.</creator><creator>Breton, P.</creator><creator>Brugel, L.</creator><creator>Calais, G.</creator><creator>Casiraghi, O.</creator><creator>Castillo, L.</creator><creator>Ceruse, P.</creator><creator>Chabolle, F.</creator><creator>Choussy, O.</creator><creator>Coste, A.</creator><creator>Costes, V.</creator><creator>Crampette, L.</creator><creator>Darrouzet, V.</creator><creator>Demez, P.</creator><creator>Devauchelle, B.</creator><creator>Dolivet, G.</creator><creator>Dufour, X.</creator><creator>Faivre, S.</creator><creator>Fakhry, N.</creator><creator>Ferron, C.</creator><creator>Floret, F.</creator><creator>Garrel, R.</creator><creator>Geoffrois, L.</creator><creator>Gilain, L.</creator><creator>Giovanni, A.</creator><creator>Girod, A.</creator><creator>Hans, S.</creator><creator>Hofman, P.</creator><creator>Housset, M.</creator><creator>Jankowski, R.</creator><creator>Jegoux, F.</creator><creator>Kaminsky, M.-C.</creator><creator>Kolb, F.</creator><creator>St Guily, J. 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Lacau ; Laccoureye, L. ; Lallemant, B. ; Lang, P. ; Lartigau, E. ; Lavieille, J.-P. ; Lefevre, M. ; Malard, O. ; Mauvais, O. ; Merol, J.-C. ; Michel, J. ; Morinière, S. ; Moulin, G. ; Poissonnet, G. ; Prades, J.-M. ; Radulesco, T. ; de Raucourt, D. ; Reyt, E. ; Righini, C. ; Robin, Y. Marie ; Rolland, F. ; Sarroul, N. ; Schultz, P. ; Sterkers, O. ; Strunski, V. ; Tassart, M. ; Testelin, S. ; Thariat, J. ; Timochenko, A. ; Toussaint, B. ; Van den Abbeele, T. ; Varoquaux, A. ; Veillon, F. ; Vergez, S. ; Wassef, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-72228d49aeae2107372e5a6c60d3ec900cf78ca203d422b8ad4533d11c9ad0a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Cancer</topic><topic>Carcinoma, Mucoepidermoid - secondary</topic><topic>Carcinoma, Mucoepidermoid - therapy</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Databases, Factual</topic><topic>Diabetes Complications - complications</topic><topic>Disease-Free Survival</topic><topic>Follow-Up Studies</topic><topic>France</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>Mucoepidermoid carcinoma</topic><topic>Neck Dissection</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Parotid gland</topic><topic>Prospective Studies</topic><topic>Radiotherapy, Adjuvant</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Gland Neoplasms - therapy</topic><topic>Salivary glands</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giorgi, Roch</creatorcontrib><creatorcontrib>Vergez, Sébastien</creatorcontrib><creatorcontrib>Le Taillandier de Gabory, Ludovic</creatorcontrib><creatorcontrib>Costes-Martineau, Valérie</creatorcontrib><creatorcontrib>Herman, Philippe</creatorcontrib><creatorcontrib>Mauvais, Olivier</creatorcontrib><creatorcontrib>Malard, Olivier</creatorcontrib><creatorcontrib>Garrel, Renaud</creatorcontrib><creatorcontrib>Barry, Béatrix</creatorcontrib><creatorcontrib>Bach, Christine</creatorcontrib><creatorcontrib>Chevalier, Dominique</creatorcontrib><creatorcontrib>Mouawad, Francois</creatorcontrib><creatorcontrib>Merol, Jean-Claude</creatorcontrib><creatorcontrib>Bastit, Vianney</creatorcontrib><creatorcontrib>Thariat, Juliette</creatorcontrib><creatorcontrib>Dufour, Xavier</creatorcontrib><creatorcontrib>Righini, Christian-Adrien</creatorcontrib><creatorcontrib>Moya-Plana, Antoine</creatorcontrib><creatorcontrib>Radulesco, Thomas</creatorcontrib><creatorcontrib>Michel, Justin</creatorcontrib><creatorcontrib>Baujat, Bertrand</creatorcontrib><creatorcontrib>Andry, G.</creatorcontrib><creatorcontrib>Badet, J.-M.</creatorcontrib><creatorcontrib>Badoual, C.</creatorcontrib><creatorcontrib>Baglin, A.C.</creatorcontrib><creatorcontrib>Banal, A.</creatorcontrib><creatorcontrib>Baudin, E.</creatorcontrib><creatorcontrib>Baujat, B.</creatorcontrib><creatorcontrib>Bertolus, C.</creatorcontrib><creatorcontrib>Bessède, J.-P.</creatorcontrib><creatorcontrib>Blanchard, D.</creatorcontrib><creatorcontrib>Bozorg-Grayeli, A.</creatorcontrib><creatorcontrib>Breheret, R.</creatorcontrib><creatorcontrib>Breton, P.</creatorcontrib><creatorcontrib>Brugel, L.</creatorcontrib><creatorcontrib>Calais, G.</creatorcontrib><creatorcontrib>Casiraghi, O.</creatorcontrib><creatorcontrib>Castillo, L.</creatorcontrib><creatorcontrib>Ceruse, P.</creatorcontrib><creatorcontrib>Chabolle, F.</creatorcontrib><creatorcontrib>Choussy, O.</creatorcontrib><creatorcontrib>Coste, A.</creatorcontrib><creatorcontrib>Costes, V.</creatorcontrib><creatorcontrib>Crampette, L.</creatorcontrib><creatorcontrib>Darrouzet, V.</creatorcontrib><creatorcontrib>Demez, P.</creatorcontrib><creatorcontrib>Devauchelle, B.</creatorcontrib><creatorcontrib>Dolivet, G.</creatorcontrib><creatorcontrib>Dufour, X.</creatorcontrib><creatorcontrib>Faivre, S.</creatorcontrib><creatorcontrib>Fakhry, N.</creatorcontrib><creatorcontrib>Ferron, C.</creatorcontrib><creatorcontrib>Floret, F.</creatorcontrib><creatorcontrib>Garrel, R.</creatorcontrib><creatorcontrib>Geoffrois, L.</creatorcontrib><creatorcontrib>Gilain, L.</creatorcontrib><creatorcontrib>Giovanni, A.</creatorcontrib><creatorcontrib>Girod, A.</creatorcontrib><creatorcontrib>Hans, S.</creatorcontrib><creatorcontrib>Hofman, P.</creatorcontrib><creatorcontrib>Housset, M.</creatorcontrib><creatorcontrib>Jankowski, R.</creatorcontrib><creatorcontrib>Jegoux, F.</creatorcontrib><creatorcontrib>Kaminsky, M.-C.</creatorcontrib><creatorcontrib>Kolb, F.</creatorcontrib><creatorcontrib>St Guily, J. Lacau</creatorcontrib><creatorcontrib>Laccoureye, L.</creatorcontrib><creatorcontrib>Lallemant, B.</creatorcontrib><creatorcontrib>Lang, P.</creatorcontrib><creatorcontrib>Lartigau, E.</creatorcontrib><creatorcontrib>Lavieille, J.-P.</creatorcontrib><creatorcontrib>Lefevre, M.</creatorcontrib><creatorcontrib>Malard, O.</creatorcontrib><creatorcontrib>Mauvais, O.</creatorcontrib><creatorcontrib>Merol, J.-C.</creatorcontrib><creatorcontrib>Michel, J.</creatorcontrib><creatorcontrib>Morinière, S.</creatorcontrib><creatorcontrib>Moulin, G.</creatorcontrib><creatorcontrib>Poissonnet, G.</creatorcontrib><creatorcontrib>Prades, J.-M.</creatorcontrib><creatorcontrib>Radulesco, T.</creatorcontrib><creatorcontrib>de Raucourt, D.</creatorcontrib><creatorcontrib>Reyt, E.</creatorcontrib><creatorcontrib>Righini, C.</creatorcontrib><creatorcontrib>Robin, Y. Marie</creatorcontrib><creatorcontrib>Rolland, F.</creatorcontrib><creatorcontrib>Sarroul, N.</creatorcontrib><creatorcontrib>Schultz, P.</creatorcontrib><creatorcontrib>Sterkers, O.</creatorcontrib><creatorcontrib>Strunski, V.</creatorcontrib><creatorcontrib>Tassart, M.</creatorcontrib><creatorcontrib>Testelin, S.</creatorcontrib><creatorcontrib>Thariat, J.</creatorcontrib><creatorcontrib>Timochenko, A.</creatorcontrib><creatorcontrib>Toussaint, B.</creatorcontrib><creatorcontrib>Van den Abbeele, T.</creatorcontrib><creatorcontrib>Varoquaux, A.</creatorcontrib><creatorcontrib>Veillon, F.</creatorcontrib><creatorcontrib>Vergez, S.</creatorcontrib><creatorcontrib>Wassef, M.</creatorcontrib><creatorcontrib>REFCOR members</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giorgi, Roch</au><au>Vergez, Sébastien</au><au>Le Taillandier de Gabory, Ludovic</au><au>Costes-Martineau, Valérie</au><au>Herman, Philippe</au><au>Mauvais, Olivier</au><au>Malard, Olivier</au><au>Garrel, Renaud</au><au>Barry, Béatrix</au><au>Bach, Christine</au><au>Chevalier, Dominique</au><au>Mouawad, Francois</au><au>Merol, Jean-Claude</au><au>Bastit, Vianney</au><au>Thariat, Juliette</au><au>Dufour, Xavier</au><au>Righini, Christian-Adrien</au><au>Moya-Plana, Antoine</au><au>Radulesco, Thomas</au><au>Michel, Justin</au><au>Baujat, Bertrand</au><au>Andry, G.</au><au>Badet, J.-M.</au><au>Badoual, C.</au><au>Baglin, A.C.</au><au>Banal, A.</au><au>Baudin, E.</au><au>Baujat, B.</au><au>Bertolus, C.</au><au>Bessède, J.-P.</au><au>Blanchard, D.</au><au>Bozorg-Grayeli, A.</au><au>Breheret, R.</au><au>Breton, P.</au><au>Brugel, L.</au><au>Calais, G.</au><au>Casiraghi, O.</au><au>Castillo, L.</au><au>Ceruse, P.</au><au>Chabolle, F.</au><au>Choussy, O.</au><au>Coste, A.</au><au>Costes, V.</au><au>Crampette, L.</au><au>Darrouzet, V.</au><au>Demez, P.</au><au>Devauchelle, B.</au><au>Dolivet, G.</au><au>Dufour, X.</au><au>Faivre, S.</au><au>Fakhry, N.</au><au>Ferron, C.</au><au>Floret, F.</au><au>Garrel, R.</au><au>Geoffrois, L.</au><au>Gilain, L.</au><au>Giovanni, A.</au><au>Girod, A.</au><au>Hans, S.</au><au>Hofman, P.</au><au>Housset, M.</au><au>Jankowski, R.</au><au>Jegoux, F.</au><au>Kaminsky, M.-C.</au><au>Kolb, F.</au><au>St Guily, J. Lacau</au><au>Laccoureye, L.</au><au>Lallemant, B.</au><au>Lang, P.</au><au>Lartigau, E.</au><au>Lavieille, J.-P.</au><au>Lefevre, M.</au><au>Malard, O.</au><au>Mauvais, O.</au><au>Merol, J.-C.</au><au>Michel, J.</au><au>Morinière, S.</au><au>Moulin, G.</au><au>Poissonnet, G.</au><au>Prades, J.-M.</au><au>Radulesco, T.</au><au>de Raucourt, D.</au><au>Reyt, E.</au><au>Righini, C.</au><au>Robin, Y. Marie</au><au>Rolland, F.</au><au>Sarroul, N.</au><au>Schultz, P.</au><au>Sterkers, O.</au><au>Strunski, V.</au><au>Tassart, M.</au><au>Testelin, S.</au><au>Thariat, J.</au><au>Timochenko, A.</au><au>Toussaint, B.</au><au>Van den Abbeele, T.</au><au>Varoquaux, A.</au><au>Veillon, F.</au><au>Vergez, S.</au><au>Wassef, M.</au><aucorp>REFCOR members</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>47</volume><issue>6</issue><spage>1376</spage><epage>1383</epage><pages>1376-1383</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.
Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.
A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.
Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33248902</pmid><doi>10.1016/j.ejso.2020.11.123</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9099-6371</orcidid><orcidid>https://orcid.org/0000-0002-5939-5372</orcidid><orcidid>https://orcid.org/0000-0003-1260-1762</orcidid><orcidid>https://orcid.org/0000-0001-6307-2907</orcidid><orcidid>https://orcid.org/0000-0001-9771-3418</orcidid><orcidid>https://orcid.org/0000-0003-1783-5066</orcidid><orcidid>https://orcid.org/0000-0001-7394-1301</orcidid><orcidid>https://orcid.org/0000-0003-3930-3191</orcidid><orcidid>https://orcid.org/0000-0002-9022-4352</orcidid><orcidid>https://orcid.org/0000-0001-6135-3078</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0748-7983 |
| ispartof | European journal of surgical oncology, 2021-06, Vol.47 (6), p.1376-1383 |
| issn | 0748-7983 1532-2157 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03049061v1 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Alcohol Drinking - adverse effects Cancer Carcinoma, Mucoepidermoid - secondary Carcinoma, Mucoepidermoid - therapy Chemoradiotherapy, Adjuvant Databases, Factual Diabetes Complications - complications Disease-Free Survival Follow-Up Studies France Humans Life Sciences Lymphatic Metastasis Middle Aged Mucoepidermoid carcinoma Neck Dissection Neoplasm Grading Neoplasm Recurrence, Local - pathology Neoplasm Staging Parotid gland Prospective Studies Radiotherapy, Adjuvant Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - therapy Salivary glands Survival Rate Young Adult |
| title | Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T18%3A27%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mucoepidermoid%20carcinoma%20of%20salivary%20glands:%20A%20French%20Network%20of%20Rare%20Head%20and%20Neck%20Tumors%20(REFCOR)%20prospective%20study%20of%20292%20cases&rft.jtitle=European%20journal%20of%20surgical%20oncology&rft.au=Giorgi,%20Roch&rft.aucorp=REFCOR%20members&rft.date=2021-06-01&rft.volume=47&rft.issue=6&rft.spage=1376&rft.epage=1383&rft.pages=1376-1383&rft.issn=0748-7983&rft.eissn=1532-2157&rft_id=info:doi/10.1016/j.ejso.2020.11.123&rft_dat=%3Cproquest_hal_p%3E2465765073%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2465765073&rft_id=info:pmid/33248902&rft_els_id=S0748798320310192&rfr_iscdi=true |