An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Gene therapy using small interfering RNA (siRNA) is emerging as a novel therapeutic approach to treat various diseases. However, safe and efficient siRNA delivery still constitutes the major obstacle for clinical implementation of siRNA therapeutics. Here we report an ionizable supramolecular dendri...

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Veröffentlicht in:	Nano research 2021-07, Vol.14 (7), p.2247-2254
Hauptverfasser:	Dhumal, Dinesh, Lan, Wenjun, Ding, Ling, Jiang, Yifan, Lyu, Zhenbin, Laurini, Erik, Marson, Domenico, Tintaru, Aura, Dusetti, Nelson, Giorgio, Suzanne, Iovanna, Juan Lucio, Pricl, Sabrina, Peng, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT2 protein Atomic/Molecular Structure and Spectra Biocompatibility Biomedical materials Biomedicine Biotechnology Cancer Chemical Sciences Chemistry and Materials Science Condensed Matter Physics Cytotoxicity Electrostatic properties Gene therapy Life Sciences Materials Science Myc protein Nanotechnology Organoids Research Article Safety Self-assembly siRNA Surface charge Toxicity Tumor cell lines
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