Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells

The nuclear factor of activated T cells (NFAT) family of transcription factors is pivotal for T lymphocyte functionality. All relevant NFAT activation events upon T cells stimulation such as nuclear translocation, DNA binding, and transcriptional activity have been shown to be dictated by its phosph...

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Veröffentlicht in:	Molecular immunology 2008-04, Vol.45 (7), p.1863-1871
Hauptverfasser:	Valdor, Rut, Schreiber, Valérie, Saenz, Luis, Martínez, Teresa, Muñoz-Suano, Alba, Dominguez-Villar, Margarita, Ramírez, Pablo, Parrilla, Pascual, Aguado, Enrique, García-Cózar, Francisco, Yélamos, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Adult Animals Biotechnology Cell Nucleus - drug effects Cell Nucleus - metabolism Enzyme Induction - drug effects Flow Cytometry HeLa Cells Histones - metabolism Humans Ionomycin - pharmacology Jurkat Cells Life Sciences Lymphocyte Activation - drug effects Mice NFAT NFATC Transcription Factors - metabolism Nuclear retention Phosphorylation - drug effects Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Poly(ADP-ribosyl)ation Poly-ADP ribose polymerases Protein Binding - drug effects Substrate Specificity - drug effects T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - enzymology Tetradecanoylphorbol Acetate - pharmacology Transcriptional Activation - drug effects
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