Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study
Objective: To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfacto...
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| Veröffentlicht in: | Ear, nose, & throat journal nose, & throat journal, 2020-11, Vol.99 (9), p.579-583 |
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| creator | Lechien, Jerome R. Cabaraux, Pierre Chiesa-Estomba, Carlos M. Khalife, Mohamad Plzak, Jan Hans, Stéphane Martiny, Delphine Calvo-Henriquez, Christian Barillari, Maria R. Hopkins, Claire Saussez, Sven |
| description | Objective:
To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation.
Methods:
A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration ≤12 days (group 1) and those with duration >12 days (group 2).
Results:
In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2.
Conclusions:
Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection. |
| doi_str_mv | 10.1177/0145561320929169 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03032305v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0145561320929169</sage_id><sourcerecordid>2450741088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-1735774590cc11db2cadfe567b165cbb6dcf26348c69ecab31b525b86645d1053</originalsourceid><addsrcrecordid>eNp1kc-L1DAUx4Mo7rh69yQBL3qo5uVXG2_DjLoLAzOwqx5LmqROl04yNulCj_7nps66yoKHEHjv8_3mvXwRegnkHUBZvifAhZDAKFFUgVSP0AIUp0UpKH2MFnO7mPtn6FmMN4TkgoSn6IxRLlU-C_RzFyezD8f9FDuje7ztW21SGCZ87WKKWHuL1y45k7rgcWjxavv1cl2Awp3HO5065zP1rUt7fDVa6zze-ujSPz7rKbaj_63_gJd4N4R4nO1uHb5Ko52eoyet7qN7cXefoy-fPl6vLorN9vPlarkpDOeQCiiZKEsuFDEGwDbUaNs6IcsGpDBNI61pqWS8MlI5oxsGjaCiqaTkwgIR7By9PfnudV8fh-6gh6kOuqsvlpt6rhFGGGVE3EJm35zY4xB-jPkj6kMXjet77V0YY005qUDliaqMvn6A3oRx8HmTTAlSciDVTJETZfL6cXDt_QRA6jnK-mGUWfLqznhsDs7eC_5kl4HiBET93f199b-GvwD8AKQ9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2450741088</pqid></control><display><type>article</type><title>Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lechien, Jerome R. ; Cabaraux, Pierre ; Chiesa-Estomba, Carlos M. ; Khalife, Mohamad ; Plzak, Jan ; Hans, Stéphane ; Martiny, Delphine ; Calvo-Henriquez, Christian ; Barillari, Maria R. ; Hopkins, Claire ; Saussez, Sven</creator><creatorcontrib>Lechien, Jerome R. ; Cabaraux, Pierre ; Chiesa-Estomba, Carlos M. ; Khalife, Mohamad ; Plzak, Jan ; Hans, Stéphane ; Martiny, Delphine ; Calvo-Henriquez, Christian ; Barillari, Maria R. ; Hopkins, Claire ; Saussez, Sven</creatorcontrib><description>Objective:
To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation.
Methods:
A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration ≤12 days (group 1) and those with duration >12 days (group 2).
Results:
In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2.
Conclusions:
Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection.</description><identifier>ISSN: 0145-5613</identifier><identifier>EISSN: 1942-7522</identifier><identifier>DOI: 10.1177/0145561320929169</identifier><identifier>PMID: 32469246</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Belgium ; Betacoronavirus ; Case-Control Studies ; Clinical Laboratory Techniques ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronaviruses ; COVID-19 ; COVID-19 Testing ; Diagnostic Techniques, Respiratory System ; Diagnostic tests ; Dysgeusia ; Female ; Humans ; Life Sciences ; Male ; Medical diagnosis ; Middle Aged ; Nasal Obstruction ; Odorants ; Olfaction disorders ; Olfaction Disorders - complications ; Olfaction Disorders - diagnosis ; Otolaryngology ; Pandemics ; Patient Reported Outcome Measures ; Physical Stimulation ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Prospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Smell ; Young Adult</subject><ispartof>Ear, nose, & throat journal, 2020-11, Vol.99 (9), p.579-583</ispartof><rights>The Author(s) 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-1735774590cc11db2cadfe567b165cbb6dcf26348c69ecab31b525b86645d1053</citedby><cites>FETCH-LOGICAL-c441t-1735774590cc11db2cadfe567b165cbb6dcf26348c69ecab31b525b86645d1053</cites><orcidid>0000-0001-9454-9464 ; 0000-0002-0845-0845 ; 0000-0002-3655-1854 ; 0000-0003-3580-0967 ; 0000-0002-5457-1509 ; 0000-0003-3993-1569</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0145561320929169$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0145561320929169$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,860,881,21945,27830,27901,27902,44921,45309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32469246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03032305$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lechien, Jerome R.</creatorcontrib><creatorcontrib>Cabaraux, Pierre</creatorcontrib><creatorcontrib>Chiesa-Estomba, Carlos M.</creatorcontrib><creatorcontrib>Khalife, Mohamad</creatorcontrib><creatorcontrib>Plzak, Jan</creatorcontrib><creatorcontrib>Hans, Stéphane</creatorcontrib><creatorcontrib>Martiny, Delphine</creatorcontrib><creatorcontrib>Calvo-Henriquez, Christian</creatorcontrib><creatorcontrib>Barillari, Maria R.</creatorcontrib><creatorcontrib>Hopkins, Claire</creatorcontrib><creatorcontrib>Saussez, Sven</creatorcontrib><title>Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study</title><title>Ear, nose, & throat journal</title><addtitle>Ear Nose Throat J</addtitle><description>Objective:
To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation.
Methods:
A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration ≤12 days (group 1) and those with duration >12 days (group 2).
Results:
In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2.
Conclusions:
Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection.</description><subject>Adult</subject><subject>Aged</subject><subject>Belgium</subject><subject>Betacoronavirus</subject><subject>Case-Control Studies</subject><subject>Clinical Laboratory Techniques</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Diagnostic Techniques, Respiratory System</subject><subject>Diagnostic tests</subject><subject>Dysgeusia</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Nasal Obstruction</subject><subject>Odorants</subject><subject>Olfaction disorders</subject><subject>Olfaction Disorders - complications</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Otolaryngology</subject><subject>Pandemics</subject><subject>Patient Reported Outcome Measures</subject><subject>Physical Stimulation</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Prospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>SARS-CoV-2</subject><subject>Smell</subject><subject>Young Adult</subject><issn>0145-5613</issn><issn>1942-7522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc-L1DAUx4Mo7rh69yQBL3qo5uVXG2_DjLoLAzOwqx5LmqROl04yNulCj_7nps66yoKHEHjv8_3mvXwRegnkHUBZvifAhZDAKFFUgVSP0AIUp0UpKH2MFnO7mPtn6FmMN4TkgoSn6IxRLlU-C_RzFyezD8f9FDuje7ztW21SGCZ87WKKWHuL1y45k7rgcWjxavv1cl2Awp3HO5065zP1rUt7fDVa6zze-ujSPz7rKbaj_63_gJd4N4R4nO1uHb5Ko52eoyet7qN7cXefoy-fPl6vLorN9vPlarkpDOeQCiiZKEsuFDEGwDbUaNs6IcsGpDBNI61pqWS8MlI5oxsGjaCiqaTkwgIR7By9PfnudV8fh-6gh6kOuqsvlpt6rhFGGGVE3EJm35zY4xB-jPkj6kMXjet77V0YY005qUDliaqMvn6A3oRx8HmTTAlSciDVTJETZfL6cXDt_QRA6jnK-mGUWfLqznhsDs7eC_5kl4HiBET93f199b-GvwD8AKQ9</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Lechien, Jerome R.</creator><creator>Cabaraux, Pierre</creator><creator>Chiesa-Estomba, Carlos M.</creator><creator>Khalife, Mohamad</creator><creator>Plzak, Jan</creator><creator>Hans, Stéphane</creator><creator>Martiny, Delphine</creator><creator>Calvo-Henriquez, Christian</creator><creator>Barillari, Maria R.</creator><creator>Hopkins, Claire</creator><creator>Saussez, Sven</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><general>Mci Medquest Communications Inc</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-9454-9464</orcidid><orcidid>https://orcid.org/0000-0002-0845-0845</orcidid><orcidid>https://orcid.org/0000-0002-3655-1854</orcidid><orcidid>https://orcid.org/0000-0003-3580-0967</orcidid><orcidid>https://orcid.org/0000-0002-5457-1509</orcidid><orcidid>https://orcid.org/0000-0003-3993-1569</orcidid></search><sort><creationdate>20201101</creationdate><title>Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study</title><author>Lechien, Jerome R. ; Cabaraux, Pierre ; Chiesa-Estomba, Carlos M. ; Khalife, Mohamad ; Plzak, Jan ; Hans, Stéphane ; Martiny, Delphine ; Calvo-Henriquez, Christian ; Barillari, Maria R. ; Hopkins, Claire ; Saussez, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-1735774590cc11db2cadfe567b165cbb6dcf26348c69ecab31b525b86645d1053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Belgium</topic><topic>Betacoronavirus</topic><topic>Case-Control Studies</topic><topic>Clinical Laboratory Techniques</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Diagnostic Techniques, Respiratory System</topic><topic>Diagnostic tests</topic><topic>Dysgeusia</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Nasal Obstruction</topic><topic>Odorants</topic><topic>Olfaction disorders</topic><topic>Olfaction Disorders - complications</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Otolaryngology</topic><topic>Pandemics</topic><topic>Patient Reported Outcome Measures</topic><topic>Physical Stimulation</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Prospective Studies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>SARS-CoV-2</topic><topic>Smell</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lechien, Jerome R.</creatorcontrib><creatorcontrib>Cabaraux, Pierre</creatorcontrib><creatorcontrib>Chiesa-Estomba, Carlos M.</creatorcontrib><creatorcontrib>Khalife, Mohamad</creatorcontrib><creatorcontrib>Plzak, Jan</creatorcontrib><creatorcontrib>Hans, Stéphane</creatorcontrib><creatorcontrib>Martiny, Delphine</creatorcontrib><creatorcontrib>Calvo-Henriquez, Christian</creatorcontrib><creatorcontrib>Barillari, Maria R.</creatorcontrib><creatorcontrib>Hopkins, Claire</creatorcontrib><creatorcontrib>Saussez, Sven</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Ear, nose, & throat journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lechien, Jerome R.</au><au>Cabaraux, Pierre</au><au>Chiesa-Estomba, Carlos M.</au><au>Khalife, Mohamad</au><au>Plzak, Jan</au><au>Hans, Stéphane</au><au>Martiny, Delphine</au><au>Calvo-Henriquez, Christian</au><au>Barillari, Maria R.</au><au>Hopkins, Claire</au><au>Saussez, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study</atitle><jtitle>Ear, nose, & throat journal</jtitle><addtitle>Ear Nose Throat J</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>99</volume><issue>9</issue><spage>579</spage><epage>583</epage><pages>579-583</pages><issn>0145-5613</issn><eissn>1942-7522</eissn><abstract>Objective:
To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation.
Methods:
A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration ≤12 days (group 1) and those with duration >12 days (group 2).
Results:
In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2.
Conclusions:
Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>32469246</pmid><doi>10.1177/0145561320929169</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9454-9464</orcidid><orcidid>https://orcid.org/0000-0002-0845-0845</orcidid><orcidid>https://orcid.org/0000-0002-3655-1854</orcidid><orcidid>https://orcid.org/0000-0003-3580-0967</orcidid><orcidid>https://orcid.org/0000-0002-5457-1509</orcidid><orcidid>https://orcid.org/0000-0003-3993-1569</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0145-5613 |
| ispartof | Ear, nose, & throat journal, 2020-11, Vol.99 (9), p.579-583 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Belgium Betacoronavirus Case-Control Studies Clinical Laboratory Techniques Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronaviruses COVID-19 COVID-19 Testing Diagnostic Techniques, Respiratory System Diagnostic tests Dysgeusia Female Humans Life Sciences Male Medical diagnosis Middle Aged Nasal Obstruction Odorants Olfaction disorders Olfaction Disorders - complications Olfaction Disorders - diagnosis Otolaryngology Pandemics Patient Reported Outcome Measures Physical Stimulation Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Prospective Studies Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Smell Young Adult |
| title | Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study |
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