A novel mechanism in wound healing: Laminin 332 drives MMP9/14 activity by recruiting syndecan-1 and CD44

•Re-epithelialization is a critical step in the skin wound healing response.•Keratinocytes deposit extracellular matrix laminin 332 along their path while migrating.•Matrix metalloproteinases-9 and −14 exert their proteolytic activity in epithelial podosomes in primary keratinocytes.•The laminin α3...

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Veröffentlicht in:	Matrix biology 2020-12, Vol.94, p.1-17
Hauptverfasser:	Michopoulou, Anna, Montmasson, Marine, Garnier, Cécile, Lambert, Elise, Dayan, Guila, Rousselle, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology CD44 CD44 antigen Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - genetics Cell Line Cell Proliferation - drug effects Cellular Biology Cytoskeleton Cytoskeleton - drug effects Epithelium Epithelium - growth & development Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - genetics Gelatinase B Gene Expression Regulation, Developmental - drug effects Growth factors Humans Hyaluronan Receptors - genetics Kalinin Keratinocytes Keratinocytes - drug effects Laminin Laminin 332 Life Sciences Matrix metalloproteinase Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 9 - genetics Podosome Proteoglycans Proteolysis RNA, Small Interfering - pharmacology Syndecan Syndecan-1 Syndecan-1 - genetics Wound healing Wound Healing - drug effects Wound Healing - genetics
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