TAF7 (TAFII55) Plays a Role in the Transcription Activation by c-Jun
c-Jun is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c-Jun function as a transactivator with...
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| Veröffentlicht in: | The Journal of biological chemistry 2003-06, Vol.278 (24), p.21510-21516 |
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| container_issue | 24 |
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| container_title | The Journal of biological chemistry |
| container_volume | 278 |
| creator | Munz, Christine Psichari, Eleni Mandilis, Dimitris Lavigne, Anne-Claire Spiliotaki, Maria Oehler, Thomas Davidson, Irwin Tora, Laszlo Angel, Peter Pintzas, Alexander |
| description | c-Jun is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c-Jun function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human TAF7 (formerly TAFII55), physically interacts with c-Jun through two independent interaction domains, within the N- and C-terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals. |
| doi_str_mv | 10.1074/jbc.M212764200 |
| format | Article |
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In the present study we have analyzed the mechanism of c-Jun function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human TAF7 (formerly TAFII55), physically interacts with c-Jun through two independent interaction domains, within the N- and C-terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1074/jbc.M212764200</identifier><identifier>PMID: 12676957</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blotting, Western ; Cell Line ; COS Cells ; Glutathione Transferase - metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases ; Life Sciences ; Luciferases - metabolism ; Mitogen-Activated Protein Kinases - metabolism ; Oligonucleotides - chemistry ; Phosphorylation ; Plasmids - metabolism ; Precipitin Tests ; Protein Binding ; Protein Structure, Tertiary ; Recombinant Proteins - metabolism ; TATA-Binding Protein Associated Factors - metabolism ; TATA-Binding Protein Associated Factors - physiology ; Transcription Factor AP-1 - metabolism ; Transcription Factor TFIID - metabolism ; Transcription Factor TFIID - physiology ; Transcription, Genetic ; Transcriptional Activation ; Transfection</subject><ispartof>The Journal of biological chemistry, 2003-06, Vol.278 (24), p.21510-21516</ispartof><rights>2003 © 2003 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4240-d559dd1c29f0d1fc0237741b6509f4bf904532e7c0d5fdd16f24aa7e55dfb3e83</citedby><cites>FETCH-LOGICAL-c4240-d559dd1c29f0d1fc0237741b6509f4bf904532e7c0d5fdd16f24aa7e55dfb3e83</cites><orcidid>0000-0001-7398-2250 ; 0000-0001-5533-1171 ; 0000-0001-9389-7029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12676957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03026399$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Munz, Christine</creatorcontrib><creatorcontrib>Psichari, Eleni</creatorcontrib><creatorcontrib>Mandilis, Dimitris</creatorcontrib><creatorcontrib>Lavigne, Anne-Claire</creatorcontrib><creatorcontrib>Spiliotaki, Maria</creatorcontrib><creatorcontrib>Oehler, Thomas</creatorcontrib><creatorcontrib>Davidson, Irwin</creatorcontrib><creatorcontrib>Tora, Laszlo</creatorcontrib><creatorcontrib>Angel, Peter</creatorcontrib><creatorcontrib>Pintzas, Alexander</creatorcontrib><title>TAF7 (TAFII55) Plays a Role in the Transcription Activation by c-Jun</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>c-Jun is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c-Jun function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human TAF7 (formerly TAFII55), physically interacts with c-Jun through two independent interaction domains, within the N- and C-terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals.</description><subject>Animals</subject><subject>Blotting, Western</subject><subject>Cell Line</subject><subject>COS Cells</subject><subject>Glutathione Transferase - metabolism</subject><subject>Humans</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Life Sciences</subject><subject>Luciferases - metabolism</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Oligonucleotides - chemistry</subject><subject>Phosphorylation</subject><subject>Plasmids - metabolism</subject><subject>Precipitin Tests</subject><subject>Protein Binding</subject><subject>Protein Structure, Tertiary</subject><subject>Recombinant Proteins - metabolism</subject><subject>TATA-Binding Protein Associated Factors - metabolism</subject><subject>TATA-Binding Protein Associated Factors - physiology</subject><subject>Transcription Factor AP-1 - metabolism</subject><subject>Transcription Factor TFIID - metabolism</subject><subject>Transcription Factor TFIID - physiology</subject><subject>Transcription, Genetic</subject><subject>Transcriptional Activation</subject><subject>Transfection</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtvEzEQhy0EomnLlSPyAaH2sOn4vT5GfdCgIBAKEjfL6wdxtdkN601Q_nscEtETPoxHo29-Gn0IvSUwJaD4zVPjpp8poUpyCvACTQjUrGKC_HiJJgCUVJqK-gyd5_wE5XFNXqMzQqWSWqgJulvOHhS-KnU-F-Iaf23tPmOLv_VtwKnD4yrg5WC77Ia0GVPf4Zkb087-bZs9dtWnbXeJXkXb5vDm9F-g7w_3y9vHavHl4_x2tqgcpxwqL4T2njiqI3gSHVCmFCeNFKAjb6IGLhgNyoEXsYAyUm6tCkL42LBQswt0fcxd2dZshrS2w970NpnH2cIcZsCASqb1jhT2w5HdDP2vbcijWafsQtvaLvTbbBRjUoJkBZweQTf0OQ8h_ksmYA6OTXFsnh2XhXen5G2zDv4ZP0ktwPvTmenn6ncagmlS71ZhbaiqDeWGEkEOOfURC0XZLoXBZJdC54IvK240vk__O-EP5IGR5w</recordid><startdate>20030613</startdate><enddate>20030613</enddate><creator>Munz, Christine</creator><creator>Psichari, Eleni</creator><creator>Mandilis, Dimitris</creator><creator>Lavigne, Anne-Claire</creator><creator>Spiliotaki, Maria</creator><creator>Oehler, Thomas</creator><creator>Davidson, Irwin</creator><creator>Tora, Laszlo</creator><creator>Angel, Peter</creator><creator>Pintzas, Alexander</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7398-2250</orcidid><orcidid>https://orcid.org/0000-0001-5533-1171</orcidid><orcidid>https://orcid.org/0000-0001-9389-7029</orcidid></search><sort><creationdate>20030613</creationdate><title>TAF7 (TAFII55) Plays a Role in the Transcription Activation by c-Jun</title><author>Munz, Christine ; 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Blotting, Western Cell Line COS Cells Glutathione Transferase - metabolism Humans JNK Mitogen-Activated Protein Kinases Life Sciences Luciferases - metabolism Mitogen-Activated Protein Kinases - metabolism Oligonucleotides - chemistry Phosphorylation Plasmids - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary Recombinant Proteins - metabolism TATA-Binding Protein Associated Factors - metabolism TATA-Binding Protein Associated Factors - physiology Transcription Factor AP-1 - metabolism Transcription Factor TFIID - metabolism Transcription Factor TFIID - physiology Transcription, Genetic Transcriptional Activation Transfection |
| title | TAF7 (TAFII55) Plays a Role in the Transcription Activation by c-Jun |
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