Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrom...

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Veröffentlicht in:	The American heart journal 2018-04, Vol.198, p.152-159
Hauptverfasser:	Bergmeijer, Thomas O., Reny, Jean-Luc, Pakyz, Ruth E., Gong, Li, Lewis, Joshua P., Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Horenstein, Richard B., Lee, Ming Ta Michael, Whaley, Ryan M., Montaner, Joan, Gensini, Gian Franco, Cleator, John H., Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M., Winter, Stefan, Altman, Russ B., Alexopoulos, Dimitrios, Kim, Ho-Sook, Déry, Jean-Pierre, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P., Wen, Ming-Shien, Shin, Jae Gook, Simon, Tabassome, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M., ten Berg, Jurriën M., Gurbel, Paul A., Hulot, Jean-Sebastien, Mitchell, Braxton D., Schwab, Matthias, Ritchie, Marylyn DeRiggi, Klein, Teri E., Shuldiner, Alan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - mortality Acute coronary syndromes Adenosine Adenosine diphosphate Aged Biochemistry Biochemistry, Molecular Biology Biotechnology Blood platelets Body mass index Cardiovascular disease Clopidogrel Clopidogrel - therapeutic use Consortia Coronary vessels Deoxyribonucleic acid Diabetes DNA Enzymes Female Genetic Association Studies Genetic diversity Genetic testing Genetic variance Genome-Wide Association Study Genomes Genotypes Grants Heritability Humans Internationality Intervention Ischemia Life Sciences Light transmittance Male Middle Aged Molecular Targeted Therapy Molecular Targeted Therapy - methods Neurobiology Neurons and Cognition Patients Pharmacodynamics Pharmacogenetics Pharmacogenomics Pharmacology Platelets Polymorphism Prognosis Receptors, Purinergic P2Y12 Receptors, Purinergic P2Y12 - drug effects Receptors, Purinergic P2Y12 - genetics Risk Assessment Risk factors Survival Rate Thrombosis Treatment Outcome Variability Vasodilator-stimulated phosphoprotein
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