Glucose metabolism links astroglial mitochondria to cannabinoid effects

Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses 1 – 5 . By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors 5 – 7 . However, whether the activation of astroglial re...

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Veröffentlicht in:	Nature (London) 2020-07, Vol.583 (7817), p.603-608
Hauptverfasser:	Jimenez-Blasco, Daniel, Busquets-Garcia, Arnau, Hebert-Chatelain, Etienne, Serrat, Roman, Vicente-Gutierrez, Carlos, Ioannidou, Christina, Gómez-Sotres, Paula, Lopez-Fabuel, Irene, Resch-Beusher, Monica, Resel, Eva, Arnouil, Dorian, Saraswat, Dave, Varilh, Marjorie, Cannich, Astrid, Julio-Kalajzic, Francisca, Bonilla-Del Río, Itziar, Almeida, Angeles, Puente, Nagore, Achicallende, Svein, Lopez-Rodriguez, Maria-Luz, Jollé, Charlotte, Déglon, Nicole, Pellerin, Luc, Josephine, Charlène, Bonvento, Gilles, Panatier, Aude, Lutz, Beat, Piazza, Pier-Vincenzo, Guzmán, Manuel, Bellocchio, Luigi, Bouzier-Sore, Anne-Karine, Grandes, Pedro, Bolaños, Juan P., Marsicano, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/31 14/28 42/109 42/41 42/44 631/378 64/60 692/1807 Activation Animals Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Bioenergetics Brain Cannabinoid Receptor Agonists - pharmacology Cannabinoid receptors Cannabinoids Cell receptors Cells, Cultured Dronabinol - pharmacology Electron transport chain Electron Transport Complex I - chemistry Electron Transport Complex I - metabolism Endocannabinoids Energy Metabolism - drug effects Glucose Glucose - metabolism Glycolysis Glycolysis - drug effects Humanities and Social Sciences Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1 - metabolism Hypoxia-inducible factors Kinases Lactic acid Lactic Acid - metabolism Life Sciences Male Metabolism Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membranes - metabolism multidisciplinary NADH-ubiquinone oxidoreductase Neurotransmitters Oxidation-Reduction Oxygen Phosphorylation Physiological aspects Proteins Reactive Oxygen Species - metabolism Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - metabolism Receptors Rodents Science Science (multidisciplinary) Signal transduction Social Behavior Social factors Social interaction Tetrahydrocannabinol THC
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