Helical γ‐Peptide Foldamers as Dual Inhibitors of Amyloid‐β Peptide and Islet Amyloid Polypeptide Oligomerization and Fibrillization

Type 2 diabetes (T2D) and Alzheimer's disease (AD) belong to the 10 deadliest diseases and are sorely lacking in effective treatments. Both pathologies are part of the degenerative disorders named amyloidoses, which involve the misfolding and the aggregation of amyloid peptides, hIAPP for T2D a...

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Veröffentlicht in:	Chemistry : a European journal 2020-11, Vol.26 (64), p.14612-14622
Hauptverfasser:	Kaffy, Julia, Berardet, Corentin, Mathieu, Loïc, Legrand, Baptiste, Taverna, Myriam, Halgand, Frédéric, Van Der Rest, Guillaume, Maillard, Ludovic T., Ongeri, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration aggregation Alzheimer's disease Amylin amyloid Amyloid beta-Peptides - metabolism Capillary electrophoresis Carboxylic acids Chemical Sciences Chemistry Conformation Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Electrophoresis Fibrillogenesis Fibrils Fluorescence foldamer helix Humans Inhibitors Islet Amyloid Polypeptide Mass spectrometry Mass spectroscopy Monomers Neurodegenerative diseases Oligomerization Oligomers Peptides peptidomimetic Polypeptides Protein Conformation, beta-Strand β-Amyloid
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