Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)
Purpose To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery. Methods This retrospective observational study involved a cohort of 28 patients diagnosed with i...
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Veröffentlicht in: | Clinical & translational oncology 2020-11, Vol.22 (11), p.2002-2008 |
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container_title | Clinical & translational oncology |
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creator | Puchar, A. Boudy, A. S. Selleret, L. Arfi, A. Owen, C. Bendifallah, S. Darai, E. |
description | Purpose
To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery.
Methods
This retrospective observational study involved a cohort of 28 patients diagnosed with invasive cervical cancer (20 patients) or in situ adenocarcinoma (eight patients) during pregnancy or during the year following delivery who received expert opinion from physicians of the Cancer Associé à La Grossesse (CALG) network between 2005 and 2018. Descriptive results were expressed in median, range and interquartile range (IQR).
Results
Between 2005 and 2018, 20 patients with ICC and eight with ISA received expert opinion from physicians of the CALG network. Both ICC and ISA were mostly diagnosed during pregnancy with a median term at diagnosis of 23.3 weeks of gestation (WG) for ICC and 7.3 WG for ISA. Overall, the median age at diagnosis for both ICC and ISA was 33 years. Most ICCs (
n
= 9) had FIGO stage ≥ IB2 and five underwent neoadjuvant chemotherapy at a median term of 22.5 WG. Seventeen patients with ICC underwent surgery. Three patients had medical termination of the pregnancy. Two patients experienced recurrence and three died. Median time of follow-up was 59.3 months (IQR 30.5–129.2).
Conclusion
Management of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice. |
doi_str_mv | 10.1007/s12094-020-02343-5 |
format | Article |
fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03009208v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2386277263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-bba7e5cc909196a7961ae9f3c3ea96b0172c3846385c583401846432084845363</originalsourceid><addsrcrecordid>eNp9kc1uEzEUhS0EoqXwAiyQl-1i4Pp3xt1FUZtWisQGJHaW49w0LhNPsGdS5Sl4BbY8R18Mp5N2iWTL1_d-50j2IeQjg88MoP6SGQcjK-BQtpCiUq_IKdPGVAKUen2sQTY_Tsi7nO-hdDVjb8mJ4FyCAnlKft_Gncthh9TFJQ2R5tAP1GPaBe9a6l0sNXU5dz64Hpf0IfRruk14F8tof1lkrt3nkOkqdRvar5FeJ4x-_SyN2D906Sc9n07ms0s6HbuTJ8PHv_TxD507OktdzljWxXvyZuXajB-O5xn5fn31bXpTzb_ObotF5SVXfbVYuBqV9wYMM9rVRjOHZiW8QGf0AljNvWikFo3yqhESWLlIwaGRjVRCizNyMfquXWu3KWxc2tvOBXszmdtDDwSAKfyOFfZ8ZLep-zVg7u0mZI9t6yJ2Q7ZcNJrXNdeioHxE_eFFCVcv3gzsITQ7hmZLaPYpNKuK6NPRf1hscPkieU6pAGIEchnFO0z2vhtS-fj8P9t_tgOhsQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2386277263</pqid></control><display><type>article</type><title>Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)</title><source>SpringerNature Journals</source><creator>Puchar, A. ; Boudy, A. S. ; Selleret, L. ; Arfi, A. ; Owen, C. ; Bendifallah, S. ; Darai, E.</creator><creatorcontrib>Puchar, A. ; Boudy, A. S. ; Selleret, L. ; Arfi, A. ; Owen, C. ; Bendifallah, S. ; Darai, E.</creatorcontrib><description>Purpose
To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery.
Methods
This retrospective observational study involved a cohort of 28 patients diagnosed with invasive cervical cancer (20 patients) or in situ adenocarcinoma (eight patients) during pregnancy or during the year following delivery who received expert opinion from physicians of the Cancer Associé à La Grossesse (CALG) network between 2005 and 2018. Descriptive results were expressed in median, range and interquartile range (IQR).
Results
Between 2005 and 2018, 20 patients with ICC and eight with ISA received expert opinion from physicians of the CALG network. Both ICC and ISA were mostly diagnosed during pregnancy with a median term at diagnosis of 23.3 weeks of gestation (WG) for ICC and 7.3 WG for ISA. Overall, the median age at diagnosis for both ICC and ISA was 33 years. Most ICCs (
n
= 9) had FIGO stage ≥ IB2 and five underwent neoadjuvant chemotherapy at a median term of 22.5 WG. Seventeen patients with ICC underwent surgery. Three patients had medical termination of the pregnancy. Two patients experienced recurrence and three died. Median time of follow-up was 59.3 months (IQR 30.5–129.2).
Conclusion
Management of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice.</description><identifier>ISSN: 1699-048X</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-020-02343-5</identifier><identifier>PMID: 32240504</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Gynecology and obstetrics ; Human health and pathology ; Life Sciences ; Medicine ; Medicine & Public Health ; Oncology ; Research Article</subject><ispartof>Clinical & translational oncology, 2020-11, Vol.22 (11), p.2002-2008</ispartof><rights>Federación de Sociedades Españolas de Oncología (FESEO) 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-bba7e5cc909196a7961ae9f3c3ea96b0172c3846385c583401846432084845363</citedby><cites>FETCH-LOGICAL-c425t-bba7e5cc909196a7961ae9f3c3ea96b0172c3846385c583401846432084845363</cites><orcidid>0000-0002-7308-7632 ; 0000-0002-7589-3339 ; 0000-0002-1856-036X ; 0000-0003-2083-7097 ; 0000-0001-6348-2375 ; 0000-0002-5982-4667</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-020-02343-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-020-02343-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32240504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03009208$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Puchar, A.</creatorcontrib><creatorcontrib>Boudy, A. S.</creatorcontrib><creatorcontrib>Selleret, L.</creatorcontrib><creatorcontrib>Arfi, A.</creatorcontrib><creatorcontrib>Owen, C.</creatorcontrib><creatorcontrib>Bendifallah, S.</creatorcontrib><creatorcontrib>Darai, E.</creatorcontrib><title>Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><addtitle>Clin Transl Oncol</addtitle><description>Purpose
To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery.
Methods
This retrospective observational study involved a cohort of 28 patients diagnosed with invasive cervical cancer (20 patients) or in situ adenocarcinoma (eight patients) during pregnancy or during the year following delivery who received expert opinion from physicians of the Cancer Associé à La Grossesse (CALG) network between 2005 and 2018. Descriptive results were expressed in median, range and interquartile range (IQR).
Results
Between 2005 and 2018, 20 patients with ICC and eight with ISA received expert opinion from physicians of the CALG network. Both ICC and ISA were mostly diagnosed during pregnancy with a median term at diagnosis of 23.3 weeks of gestation (WG) for ICC and 7.3 WG for ISA. Overall, the median age at diagnosis for both ICC and ISA was 33 years. Most ICCs (
n
= 9) had FIGO stage ≥ IB2 and five underwent neoadjuvant chemotherapy at a median term of 22.5 WG. Seventeen patients with ICC underwent surgery. Three patients had medical termination of the pregnancy. Two patients experienced recurrence and three died. Median time of follow-up was 59.3 months (IQR 30.5–129.2).
Conclusion
Management of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice.</description><subject>Gynecology and obstetrics</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Research Article</subject><issn>1699-048X</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc1uEzEUhS0EoqXwAiyQl-1i4Pp3xt1FUZtWisQGJHaW49w0LhNPsGdS5Sl4BbY8R18Mp5N2iWTL1_d-50j2IeQjg88MoP6SGQcjK-BQtpCiUq_IKdPGVAKUen2sQTY_Tsi7nO-hdDVjb8mJ4FyCAnlKft_Gncthh9TFJQ2R5tAP1GPaBe9a6l0sNXU5dz64Hpf0IfRruk14F8tof1lkrt3nkOkqdRvar5FeJ4x-_SyN2D906Sc9n07ms0s6HbuTJ8PHv_TxD507OktdzljWxXvyZuXajB-O5xn5fn31bXpTzb_ObotF5SVXfbVYuBqV9wYMM9rVRjOHZiW8QGf0AljNvWikFo3yqhESWLlIwaGRjVRCizNyMfquXWu3KWxc2tvOBXszmdtDDwSAKfyOFfZ8ZLep-zVg7u0mZI9t6yJ2Q7ZcNJrXNdeioHxE_eFFCVcv3gzsITQ7hmZLaPYpNKuK6NPRf1hscPkieU6pAGIEchnFO0z2vhtS-fj8P9t_tgOhsQ</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Puchar, A.</creator><creator>Boudy, A. S.</creator><creator>Selleret, L.</creator><creator>Arfi, A.</creator><creator>Owen, C.</creator><creator>Bendifallah, S.</creator><creator>Darai, E.</creator><general>Springer International Publishing</general><general>Springer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-7308-7632</orcidid><orcidid>https://orcid.org/0000-0002-7589-3339</orcidid><orcidid>https://orcid.org/0000-0002-1856-036X</orcidid><orcidid>https://orcid.org/0000-0003-2083-7097</orcidid><orcidid>https://orcid.org/0000-0001-6348-2375</orcidid><orcidid>https://orcid.org/0000-0002-5982-4667</orcidid></search><sort><creationdate>20201101</creationdate><title>Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)</title><author>Puchar, A. ; Boudy, A. S. ; Selleret, L. ; Arfi, A. ; Owen, C. ; Bendifallah, S. ; Darai, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-bba7e5cc909196a7961ae9f3c3ea96b0172c3846385c583401846432084845363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Gynecology and obstetrics</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puchar, A.</creatorcontrib><creatorcontrib>Boudy, A. S.</creatorcontrib><creatorcontrib>Selleret, L.</creatorcontrib><creatorcontrib>Arfi, A.</creatorcontrib><creatorcontrib>Owen, C.</creatorcontrib><creatorcontrib>Bendifallah, S.</creatorcontrib><creatorcontrib>Darai, E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puchar, A.</au><au>Boudy, A. S.</au><au>Selleret, L.</au><au>Arfi, A.</au><au>Owen, C.</au><au>Bendifallah, S.</au><au>Darai, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse)</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><addtitle>Clin Transl Oncol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>22</volume><issue>11</issue><spage>2002</spage><epage>2008</epage><pages>2002-2008</pages><issn>1699-048X</issn><eissn>1699-3055</eissn><abstract>Purpose
To describe the oncologic and obstetric outcomes of patients diagnosed with invasive cervical cancer (ICC) and in situ adenocarcinoma (ISA) during pregnancy or during the year following delivery.
Methods
This retrospective observational study involved a cohort of 28 patients diagnosed with invasive cervical cancer (20 patients) or in situ adenocarcinoma (eight patients) during pregnancy or during the year following delivery who received expert opinion from physicians of the Cancer Associé à La Grossesse (CALG) network between 2005 and 2018. Descriptive results were expressed in median, range and interquartile range (IQR).
Results
Between 2005 and 2018, 20 patients with ICC and eight with ISA received expert opinion from physicians of the CALG network. Both ICC and ISA were mostly diagnosed during pregnancy with a median term at diagnosis of 23.3 weeks of gestation (WG) for ICC and 7.3 WG for ISA. Overall, the median age at diagnosis for both ICC and ISA was 33 years. Most ICCs (
n
= 9) had FIGO stage ≥ IB2 and five underwent neoadjuvant chemotherapy at a median term of 22.5 WG. Seventeen patients with ICC underwent surgery. Three patients had medical termination of the pregnancy. Two patients experienced recurrence and three died. Median time of follow-up was 59.3 months (IQR 30.5–129.2).
Conclusion
Management of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32240504</pmid><doi>10.1007/s12094-020-02343-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7308-7632</orcidid><orcidid>https://orcid.org/0000-0002-7589-3339</orcidid><orcidid>https://orcid.org/0000-0002-1856-036X</orcidid><orcidid>https://orcid.org/0000-0003-2083-7097</orcidid><orcidid>https://orcid.org/0000-0001-6348-2375</orcidid><orcidid>https://orcid.org/0000-0002-5982-4667</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Gynecology and obstetrics Human health and pathology Life Sciences Medicine Medicine & Public Health Oncology Research Article |
title | Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associé à La Grossesse) |
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