Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes

Nucleus position in cells can act as a developmental cue. Mammalian oocytes position their nucleus centrally using an F-actin-mediated pressure gradient. The biological significance of nucleus centering in mammalian oocytes being unknown, we sought to assess the F-actin pressure gradient effect on t...

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Veröffentlicht in:	Developmental cell 2019-10, Vol.51 (2), p.145-157.e10
Hauptverfasser:	Almonacid, Maria, Al Jord, Adel, El-Hayek, Stephany, Othmani, Alice, Coulpier, Fanny, Lemoine, Sophie, Miyamoto, Kei, Grosse, Robert, Klein, Christophe, Piolot, Tristan, Mailly, Philippe, Voituriez, Raphaël, Genovesio, Auguste, Verlhac, Marie-Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actins - metabolism Animals bio-physics Cell Nucleus - metabolism Chromatin - metabolism Cytoplasm - metabolism F-actin Female Life Sciences Male mechano-transduction Meiosis - physiology Mice, Transgenic mouse oocyte nuclear dynamics Nuclear Envelope - metabolism Oocytes - metabolism
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