Multifocal arterial wall contrast – enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke
Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atheroscler...
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| Veröffentlicht in: | Revue neurologique 2020-03, Vol.176 (3), p.194-199 |
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| creator | Ameli, R. Eker, O. Sigovan, M. Cho, T.-H. Mechtouff, L. Hermier, M. Berner, L.-P. Nighoghossian, N. Berthezene, Y. |
| description | Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atherosclerosis.
Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration.
We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement.
At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state. |
| doi_str_mv | 10.1016/j.neurol.2019.07.022 |
| format | Article |
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Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration.
We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement.
At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state.</description><identifier>ISSN: 0035-3787</identifier><identifier>DOI: 10.1016/j.neurol.2019.07.022</identifier><identifier>PMID: 31987628</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Aged ; Aged, 80 and over ; Arteries - diagnostic imaging ; Arteries - metabolism ; Arteries - pathology ; Atherosclerotic plaque ; Bioengineering ; Brain - blood supply ; Brain - diagnostic imaging ; Carotid Artery, Internal - diagnostic imaging ; Carotid Artery, Internal - metabolism ; Carotid Artery, Internal - pathology ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - metabolism ; Carotid Stenosis - pathology ; Contrast Media - pharmacokinetics ; Female ; Gadolinium - pharmacokinetics ; High-resolution vessel wall MRI ; Humans ; Image Enhancement - methods ; Imaging ; Intracranial Arteriosclerosis - diagnostic imaging ; Intracranial Arteriosclerosis - metabolism ; Ischemic Stroke - diagnostic imaging ; Ischemic Stroke - metabolism ; Life Sciences ; Magnetic Resonance Angiography - methods ; Male ; Middle Aged ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - metabolism ; Middle Cerebral Artery - pathology ; MRI ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - metabolism ; Stroke ; Stroke - diagnostic imaging ; Stroke - metabolism ; Systemic Inflammatory Response Syndrome - diagnostic imaging ; Systemic Inflammatory Response Syndrome - metabolism</subject><ispartof>Revue neurologique, 2020-03, Vol.176 (3), p.194-199</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Masson SAS.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-e9d2736c49e72b95bbe71e9c704a90c771d3e501186bd311c066d926a1ffb9463</citedby><cites>FETCH-LOGICAL-c396t-e9d2736c49e72b95bbe71e9c704a90c771d3e501186bd311c066d926a1ffb9463</cites><orcidid>0000-0002-5696-5368 ; 0000-0002-3568-1083 ; 0000-0002-4461-2346 ; 0000-0003-0594-4409 ; 0000-0001-6725-7861 ; 0000-0001-9165-5763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurol.2019.07.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31987628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02991613$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ameli, R.</creatorcontrib><creatorcontrib>Eker, O.</creatorcontrib><creatorcontrib>Sigovan, M.</creatorcontrib><creatorcontrib>Cho, T.-H.</creatorcontrib><creatorcontrib>Mechtouff, L.</creatorcontrib><creatorcontrib>Hermier, M.</creatorcontrib><creatorcontrib>Berner, L.-P.</creatorcontrib><creatorcontrib>Nighoghossian, N.</creatorcontrib><creatorcontrib>Berthezene, Y.</creatorcontrib><title>Multifocal arterial wall contrast – enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke</title><title>Revue neurologique</title><addtitle>Rev Neurol (Paris)</addtitle><description>Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atherosclerosis.
Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration.
We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement.
At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteries - diagnostic imaging</subject><subject>Arteries - metabolism</subject><subject>Arteries - pathology</subject><subject>Atherosclerotic plaque</subject><subject>Bioengineering</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Carotid Artery, Internal - diagnostic imaging</subject><subject>Carotid Artery, Internal - metabolism</subject><subject>Carotid Artery, Internal - pathology</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - metabolism</subject><subject>Carotid Stenosis - pathology</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Female</subject><subject>Gadolinium - pharmacokinetics</subject><subject>High-resolution vessel wall MRI</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Imaging</subject><subject>Intracranial Arteriosclerosis - diagnostic imaging</subject><subject>Intracranial Arteriosclerosis - metabolism</subject><subject>Ischemic Stroke - diagnostic imaging</subject><subject>Ischemic Stroke - metabolism</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - metabolism</subject><subject>Middle Cerebral Artery - pathology</subject><subject>MRI</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - metabolism</subject><subject>Stroke</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - metabolism</subject><subject>Systemic Inflammatory Response Syndrome - diagnostic imaging</subject><subject>Systemic Inflammatory Response Syndrome - metabolism</subject><issn>0035-3787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL9u2zAQhzm0aP60b1AUXDtYuSNt0sxQwAjaJoCDLu1MUNQJpiOJBkkn8JZ3yBv2SSpHScZOPPB-3x3uY-wzQoWA6mJbDbRPsasEoKlAVyDEO3YKIBczqZf6hJ3lvAUQqEF-YCcSzVIrsTxlj7f7roQ2etdxlwqlMBYPruu4j0NJLhf-9_GJ07Bxg6eehsLDwEP2G-qD57mkeEeXfMX7kFJMPLY8H3J5boah7VzfuxLTgSfKuzhkOuLO7wu9sB_Z-9Z1mT69vOfsz4_vv6-uZ-tfP2-uVuuZl0aVGZlGaKn83JAWtVnUNWkk4zXMnQGvNTaSFoC4VHUjET0o1RihHLZtbeZKnrOv09yN6-wuhd6lg40u2OvV2h7_QBiDCuU9jtn5lPUp5pyofQMQ7FG43dpJuD0Kt6BHWozYlwnb7euemjfo1fYY-DYFaDz0PlCy2QcavTYhkS-2ieH_G_4BRBKYqw</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Ameli, R.</creator><creator>Eker, O.</creator><creator>Sigovan, M.</creator><creator>Cho, T.-H.</creator><creator>Mechtouff, L.</creator><creator>Hermier, M.</creator><creator>Berner, L.-P.</creator><creator>Nighoghossian, N.</creator><creator>Berthezene, Y.</creator><general>Elsevier Masson SAS</general><general>Elsevier Masson</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5696-5368</orcidid><orcidid>https://orcid.org/0000-0002-3568-1083</orcidid><orcidid>https://orcid.org/0000-0002-4461-2346</orcidid><orcidid>https://orcid.org/0000-0003-0594-4409</orcidid><orcidid>https://orcid.org/0000-0001-6725-7861</orcidid><orcidid>https://orcid.org/0000-0001-9165-5763</orcidid></search><sort><creationdate>202003</creationdate><title>Multifocal arterial wall contrast – enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke</title><author>Ameli, R. ; Eker, O. ; Sigovan, M. ; Cho, T.-H. ; Mechtouff, L. ; Hermier, M. ; Berner, L.-P. ; Nighoghossian, N. ; Berthezene, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-e9d2736c49e72b95bbe71e9c704a90c771d3e501186bd311c066d926a1ffb9463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteries - diagnostic imaging</topic><topic>Arteries - metabolism</topic><topic>Arteries - pathology</topic><topic>Atherosclerotic plaque</topic><topic>Bioengineering</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Carotid Artery, Internal - diagnostic imaging</topic><topic>Carotid Artery, Internal - metabolism</topic><topic>Carotid Artery, Internal - pathology</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - metabolism</topic><topic>Carotid Stenosis - pathology</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Female</topic><topic>Gadolinium - pharmacokinetics</topic><topic>High-resolution vessel wall MRI</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Imaging</topic><topic>Intracranial Arteriosclerosis - diagnostic imaging</topic><topic>Intracranial Arteriosclerosis - metabolism</topic><topic>Ischemic Stroke - diagnostic imaging</topic><topic>Ischemic Stroke - metabolism</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - metabolism</topic><topic>Middle Cerebral Artery - pathology</topic><topic>MRI</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - metabolism</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - metabolism</topic><topic>Systemic Inflammatory Response Syndrome - diagnostic imaging</topic><topic>Systemic Inflammatory Response Syndrome - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ameli, R.</creatorcontrib><creatorcontrib>Eker, O.</creatorcontrib><creatorcontrib>Sigovan, M.</creatorcontrib><creatorcontrib>Cho, T.-H.</creatorcontrib><creatorcontrib>Mechtouff, L.</creatorcontrib><creatorcontrib>Hermier, M.</creatorcontrib><creatorcontrib>Berner, L.-P.</creatorcontrib><creatorcontrib>Nighoghossian, N.</creatorcontrib><creatorcontrib>Berthezene, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Revue neurologique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ameli, R.</au><au>Eker, O.</au><au>Sigovan, M.</au><au>Cho, T.-H.</au><au>Mechtouff, L.</au><au>Hermier, M.</au><au>Berner, L.-P.</au><au>Nighoghossian, N.</au><au>Berthezene, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifocal arterial wall contrast – enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke</atitle><jtitle>Revue neurologique</jtitle><addtitle>Rev Neurol (Paris)</addtitle><date>2020-03</date><risdate>2020</risdate><volume>176</volume><issue>3</issue><spage>194</spage><epage>199</epage><pages>194-199</pages><issn>0035-3787</issn><abstract>Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atherosclerosis.
Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration.
We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement.
At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>31987628</pmid><doi>10.1016/j.neurol.2019.07.022</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5696-5368</orcidid><orcidid>https://orcid.org/0000-0002-3568-1083</orcidid><orcidid>https://orcid.org/0000-0002-4461-2346</orcidid><orcidid>https://orcid.org/0000-0003-0594-4409</orcidid><orcidid>https://orcid.org/0000-0001-6725-7861</orcidid><orcidid>https://orcid.org/0000-0001-9165-5763</orcidid></addata></record> |
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| ispartof | Revue neurologique, 2020-03, Vol.176 (3), p.194-199 |
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| language | eng |
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| subjects | Aged Aged, 80 and over Arteries - diagnostic imaging Arteries - metabolism Arteries - pathology Atherosclerotic plaque Bioengineering Brain - blood supply Brain - diagnostic imaging Carotid Artery, Internal - diagnostic imaging Carotid Artery, Internal - metabolism Carotid Artery, Internal - pathology Carotid Stenosis - diagnostic imaging Carotid Stenosis - metabolism Carotid Stenosis - pathology Contrast Media - pharmacokinetics Female Gadolinium - pharmacokinetics High-resolution vessel wall MRI Humans Image Enhancement - methods Imaging Intracranial Arteriosclerosis - diagnostic imaging Intracranial Arteriosclerosis - metabolism Ischemic Stroke - diagnostic imaging Ischemic Stroke - metabolism Life Sciences Magnetic Resonance Angiography - methods Male Middle Aged Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - metabolism Middle Cerebral Artery - pathology MRI Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - metabolism Stroke Stroke - diagnostic imaging Stroke - metabolism Systemic Inflammatory Response Syndrome - diagnostic imaging Systemic Inflammatory Response Syndrome - metabolism |
| title | Multifocal arterial wall contrast – enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke |
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