Synthesis and biological properties of conjugates between fluoroquinolones and a N3''-functionalized pyochelin

Pyochelin is a siderophore common to Pseudomonas aeruginosa and several other pathogenic bacteria. A pyochelin functionalized at the N3'' position with a propyl-amine extension was previously synthesized. In the present work we proved that this analog binds FptA, the pyochelin outer membra...

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Veröffentlicht in:Organic & biomolecular chemistry 2011-12, Vol.9 (24), p.8288-8300
Hauptverfasser: Noël, Sabrina, Gasser, Véronique, Pesset, Bénédicte, Hoegy, Françoise, Rognan, Didier, Schalk, Isabelle J, Mislin, Gaëtan L A
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Sprache:eng
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