Postreplication repair mechanisms in the presence of DNA adducts in Escherichia coli

During bacterial replication, DNA polymerases may encounter DNA lesions that block processive DNA synthesis. Uncoupling the replicative helicase from the stalled DNA polymerase results in the formation of single-stranded DNA (ssDNA) gaps, which are repaired by postreplication repair (PRR), a process...

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Veröffentlicht in:	Mutation research 2011-05, Vol.727 (3), p.104-122
Hauptverfasser:	Bichara, Marc, Meier, Matthew J., Wagner, Jérome, Cordonnier, Agnès, Lambert, Iain B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology DNA Adducts DNA Repair DNA Replication DNA, Bacterial - genetics DNA, Cruciform - metabolism DNA-Directed DNA Polymerase - metabolism Escherichia coli Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Genic rearrangement. Recombination. Transposable element Life Sciences Models, Biological Molecular and cellular biology Molecular genetics Mutagenesis. Repair Postreplication repair Protein Processing, Post-Translational Recombination SOS Response (Genetics) ssDNA gap repair Translesion synthesis
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