Neuroprotective brain-derived neurotrophic factor signaling in the TAU-P301L tauopathy zebrafish model

[Display omitted] •Expressing human TAU-P301L mutation in Zebrafish neurons leads to BDNF expression decrease without affecting TrkB expression.•BDNF level reduction is associated with axonal development defects and neuronal death within 48hpf.•TrkB antagonist ANA-12 and TAU-P301L leads to comparabl...

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Veröffentlicht in:	Pharmacological research 2020-08, Vol.158, p.104865, Article 104865
Hauptverfasser:	Barbereau, Clément, Yehya, Alaa, Silhol, Michelle, Cubedo, Nicolas, Verdier, Jean-Michel, Maurice, Tangui, Rossel, Mireille
Format:	Artikel
Sprache:	eng
Schlagworte:	BDNF signaling Life Sciences Neurobiology Neurons and Cognition TAU-P301L mutation Tauopathies TrkB Zebrafish
Online-Zugang:	Volltext
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