Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

Cellular differentiation entails loss of pluripotency and gain of lineage- and cell-type-specific characteristics. Using a murine system that progresses from stem cells to lineage-committed progenitors to terminally differentiated neurons, we analyzed DNA methylation and Polycomb-mediated histone H3...

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Veröffentlicht in:	Molecular cell 2008-06, Vol.30 (6), p.755-766
Hauptverfasser:	Mohn, Fabio, Weber, Michael, Rebhan, Michael, Roloff, Tim C., Richter, Jens, Stadler, Michael B., Bibel, Miriam, Schübeler, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry, Molecular Biology Cell Differentiation Dinucleoside Phosphates DNA DNA Methylation Eye Proteins - physiology Homeodomain Proteins - physiology Humans Life Sciences Models, Biological Neurons - cytology Neurons - physiology Paired Box Transcription Factors - physiology PAX6 Transcription Factor Pluripotent Stem Cells - cytology Pluripotent Stem Cells - physiology Polycomb-Group Proteins Promoter Regions, Genetic Repressor Proteins - physiology STEMCELL
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