Amphiphilic diblock and triblock copolymers based on poly(2-methyl-2-oxazoline) and poly(D,L-lactide): Synthesis, physicochemical characterizations and self-assembly properties
A range of amphiphilic diblock and triblock copolymers based on poly (2-methyl-2-oxazoline) (PMeOx) and poly (D,L-lactide) (PLA) with various compositions and molecular masses were prepared combining cationic ring-opening polymerization and click chemistry. Their hydrophilic weight ratios (f) covere...
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| Veröffentlicht in: | Polymer (Guilford) 2019-05, Vol.171, p.149-160 |
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| creator | Le Fer, Gaëlle Le Cœur, Clémence Guigner, Jean-Michel Amiel, Catherine Volet, Gisèle |
| description | A range of amphiphilic diblock and triblock copolymers based on poly (2-methyl-2-oxazoline) (PMeOx) and poly (D,L-lactide) (PLA) with various compositions and molecular masses were prepared combining cationic ring-opening polymerization and click chemistry. Their hydrophilic weight ratios (f) covered a wide range of composition (21–77%). In water, these amphiphilic copolymers self-assembled to form, in the case of diblock copolymers, core-shell micellar structures with a dense PLA core and a hydrated PMeOx shell in the whole range of f values. The triblock copolymers formed micellar aggregates of finite sizes made of bridged micelles, the micelles being connected by some of the PLA end-blocks. Moreover, the micelles displayed original core-multishell nanostructures in a specific range of f values (48%), never reported for this kind of triblock copolymers. The amphiphilic copolymers of this study displayed a rich variety of controlled self-assembled morphologies which could be promising candidates for drug delivery applications.
[Display omitted]
•PMeOx-b-PLA and PLA-b-PMeOx-b-PLA were prepared combining CROP and click chemistry.•Copolymers self-assembled via nanoprecipitation or dialysis.•Spherical nano-objects were analyzed by cryo-TEM, DLS and SANS.•Bridged micelles were formed with triblock copolymers.•Core-multishell structures were formed at f = 48%. |
| doi_str_mv | 10.1016/j.polymer.2019.03.037 |
| format | Article |
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[Display omitted]
•PMeOx-b-PLA and PLA-b-PMeOx-b-PLA were prepared combining CROP and click chemistry.•Copolymers self-assembled via nanoprecipitation or dialysis.•Spherical nano-objects were analyzed by cryo-TEM, DLS and SANS.•Bridged micelles were formed with triblock copolymers.•Core-multishell structures were formed at f = 48%.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2019.03.037</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Block copolymers ; Cationic polymerization ; Chemical Sciences ; Chemical synthesis ; Composition ; Copolymers ; Drug delivery ; Drug delivery systems ; Micelles ; Morphology ; Organic chemistry ; poly(2-methyl-2-oxazoline) ; Polymerization ; Ring opening polymerization ; Self-assembly ; Small-angle neutron scattering</subject><ispartof>Polymer (Guilford), 2019-05, Vol.171, p.149-160</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright Elsevier BV May 8, 2019</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-dca84f9dd51760d8c05edd2ad6159cbec67df4ef74c85cf0b9b7876c0ecf9c0e3</citedby><cites>FETCH-LOGICAL-c455t-dca84f9dd51760d8c05edd2ad6159cbec67df4ef74c85cf0b9b7876c0ecf9c0e3</cites><orcidid>0000-0003-1747-7895 ; 0000-0003-4412-338X ; 0000-0003-1129-3665</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0032386119302617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://hal.science/hal-02952302$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Fer, Gaëlle</creatorcontrib><creatorcontrib>Le Cœur, Clémence</creatorcontrib><creatorcontrib>Guigner, Jean-Michel</creatorcontrib><creatorcontrib>Amiel, Catherine</creatorcontrib><creatorcontrib>Volet, Gisèle</creatorcontrib><title>Amphiphilic diblock and triblock copolymers based on poly(2-methyl-2-oxazoline) and poly(D,L-lactide): Synthesis, physicochemical characterizations and self-assembly properties</title><title>Polymer (Guilford)</title><description>A range of amphiphilic diblock and triblock copolymers based on poly (2-methyl-2-oxazoline) (PMeOx) and poly (D,L-lactide) (PLA) with various compositions and molecular masses were prepared combining cationic ring-opening polymerization and click chemistry. Their hydrophilic weight ratios (f) covered a wide range of composition (21–77%). In water, these amphiphilic copolymers self-assembled to form, in the case of diblock copolymers, core-shell micellar structures with a dense PLA core and a hydrated PMeOx shell in the whole range of f values. The triblock copolymers formed micellar aggregates of finite sizes made of bridged micelles, the micelles being connected by some of the PLA end-blocks. Moreover, the micelles displayed original core-multishell nanostructures in a specific range of f values (48%), never reported for this kind of triblock copolymers. The amphiphilic copolymers of this study displayed a rich variety of controlled self-assembled morphologies which could be promising candidates for drug delivery applications.
[Display omitted]
•PMeOx-b-PLA and PLA-b-PMeOx-b-PLA were prepared combining CROP and click chemistry.•Copolymers self-assembled via nanoprecipitation or dialysis.•Spherical nano-objects were analyzed by cryo-TEM, DLS and SANS.•Bridged micelles were formed with triblock copolymers.•Core-multishell structures were formed at f = 48%.</description><subject>Block copolymers</subject><subject>Cationic polymerization</subject><subject>Chemical Sciences</subject><subject>Chemical synthesis</subject><subject>Composition</subject><subject>Copolymers</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Micelles</subject><subject>Morphology</subject><subject>Organic chemistry</subject><subject>poly(2-methyl-2-oxazoline)</subject><subject>Polymerization</subject><subject>Ring opening polymerization</subject><subject>Self-assembly</subject><subject>Small-angle neutron scattering</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFUdtq3DAQNaWBbtN-QkHQly5EW0m2fOlLWdJLCgt5SPos5NEYaytbruSEOF_VT6z2Ql8LhxEzc85hRpNl7zjbcMbLj_vN5N0yYNgIxpsNyxOqF9mK11VOhWj4y2zFWC5oXpf8VfY6xj1jTEhRrLI_22HqbYKzQIxtnYdfRI-GzOGcgD-7R9LqiIb4kRwqHwQdcO4XRwX1T_rZOzvi-qg9tr9c7ajTMFuD60_kbhnnHqONV2Tql2jBQ4-DBe0I9DokHgb7rGfrx3j0iOg6qmPEoXULmYKfMMwW45vsotMu4tvze5n9_Pb1_vqG7m6__7je7igUUs7UgK6LrjFG8qpkpgYm0RihTcllAy1CWZmuwK4qoJbQsbZpq7oqgSF0TYr5ZbY--fbaqSnYQYdFeW3VzXanDjUmGilyJh554r4_cdOYvx8wzmrvH8KYxlNCiKrgpazLxJInFgQfY8Duny1n6nBItVfnr1aHQyqWJ1RJ9_mkw7Tuo03dCBZHQGMDwqyMt_9x-AsDoK5b</recordid><startdate>20190508</startdate><enddate>20190508</enddate><creator>Le Fer, Gaëlle</creator><creator>Le Cœur, Clémence</creator><creator>Guigner, Jean-Michel</creator><creator>Amiel, Catherine</creator><creator>Volet, Gisèle</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-1747-7895</orcidid><orcidid>https://orcid.org/0000-0003-4412-338X</orcidid><orcidid>https://orcid.org/0000-0003-1129-3665</orcidid></search><sort><creationdate>20190508</creationdate><title>Amphiphilic diblock and triblock copolymers based on poly(2-methyl-2-oxazoline) and poly(D,L-lactide): Synthesis, physicochemical characterizations and self-assembly properties</title><author>Le Fer, Gaëlle ; Le Cœur, Clémence ; Guigner, Jean-Michel ; Amiel, Catherine ; Volet, Gisèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-dca84f9dd51760d8c05edd2ad6159cbec67df4ef74c85cf0b9b7876c0ecf9c0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Block copolymers</topic><topic>Cationic polymerization</topic><topic>Chemical Sciences</topic><topic>Chemical synthesis</topic><topic>Composition</topic><topic>Copolymers</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Micelles</topic><topic>Morphology</topic><topic>Organic chemistry</topic><topic>poly(2-methyl-2-oxazoline)</topic><topic>Polymerization</topic><topic>Ring opening polymerization</topic><topic>Self-assembly</topic><topic>Small-angle neutron scattering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Fer, Gaëlle</creatorcontrib><creatorcontrib>Le Cœur, Clémence</creatorcontrib><creatorcontrib>Guigner, Jean-Michel</creatorcontrib><creatorcontrib>Amiel, Catherine</creatorcontrib><creatorcontrib>Volet, Gisèle</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Polymer (Guilford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Fer, Gaëlle</au><au>Le Cœur, Clémence</au><au>Guigner, Jean-Michel</au><au>Amiel, Catherine</au><au>Volet, Gisèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amphiphilic diblock and triblock copolymers based on poly(2-methyl-2-oxazoline) and poly(D,L-lactide): Synthesis, physicochemical characterizations and self-assembly properties</atitle><jtitle>Polymer (Guilford)</jtitle><date>2019-05-08</date><risdate>2019</risdate><volume>171</volume><spage>149</spage><epage>160</epage><pages>149-160</pages><issn>0032-3861</issn><eissn>1873-2291</eissn><abstract>A range of amphiphilic diblock and triblock copolymers based on poly (2-methyl-2-oxazoline) (PMeOx) and poly (D,L-lactide) (PLA) with various compositions and molecular masses were prepared combining cationic ring-opening polymerization and click chemistry. Their hydrophilic weight ratios (f) covered a wide range of composition (21–77%). In water, these amphiphilic copolymers self-assembled to form, in the case of diblock copolymers, core-shell micellar structures with a dense PLA core and a hydrated PMeOx shell in the whole range of f values. The triblock copolymers formed micellar aggregates of finite sizes made of bridged micelles, the micelles being connected by some of the PLA end-blocks. Moreover, the micelles displayed original core-multishell nanostructures in a specific range of f values (48%), never reported for this kind of triblock copolymers. The amphiphilic copolymers of this study displayed a rich variety of controlled self-assembled morphologies which could be promising candidates for drug delivery applications.
[Display omitted]
•PMeOx-b-PLA and PLA-b-PMeOx-b-PLA were prepared combining CROP and click chemistry.•Copolymers self-assembled via nanoprecipitation or dialysis.•Spherical nano-objects were analyzed by cryo-TEM, DLS and SANS.•Bridged micelles were formed with triblock copolymers.•Core-multishell structures were formed at f = 48%.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2019.03.037</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1747-7895</orcidid><orcidid>https://orcid.org/0000-0003-4412-338X</orcidid><orcidid>https://orcid.org/0000-0003-1129-3665</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0032-3861 |
| ispartof | Polymer (Guilford), 2019-05, Vol.171, p.149-160 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Block copolymers Cationic polymerization Chemical Sciences Chemical synthesis Composition Copolymers Drug delivery Drug delivery systems Micelles Morphology Organic chemistry poly(2-methyl-2-oxazoline) Polymerization Ring opening polymerization Self-assembly Small-angle neutron scattering |
| title | Amphiphilic diblock and triblock copolymers based on poly(2-methyl-2-oxazoline) and poly(D,L-lactide): Synthesis, physicochemical characterizations and self-assembly properties |
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