Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement

•POH and LIM improve the regeneration process.•POH and LIM improve the sensory and motor function recovery.•These effects are due the anti-inflammatory effect and upregulation of the neurotrophic process. Limonene (LIM) and its main metabolite perillyl alcohol (POH) are ingredients found in food wit...

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Veröffentlicht in:	International immunopharmacology 2020-09, Vol.86, p.106766-106766, Article 106766
Hauptverfasser:	Araújo-Filho, Heitor G., Pereira, Erik W.M., Heimfarth, Luana, Souza Monteiro, Brenda, Santos Passos, Fabiolla Rocha, Siqueira-Lima, Pollyana, Gandhi, Sathiyabama R., Viana dos Santos, Márcio Roberto, Guedes da Silva Almeida, Jackson Roberto, Picot, Laurent, Grougnet, Raphaël, Almeida, Ray S., Douglas Melo Coutinho, Henrique, Quintans-Júnior, Lucindo J., Martins, Natália, Quintans, Jullyana S.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biochemistry, Molecular Biology D-limonene Enzyme-linked immunosorbent assay Extracellular signal-regulated kinase Food additives Gait GAP-43 protein Glial fibrillary acidic protein Gliosis IL-1β Immunofluorescence Inflammation Life Sciences Limonene Medication Metabolites Monoterpenes Muscle strength Natural products Nerve growth factor Nerve regeneration Neuropathic pain Pain Pain perception Perillyl alcohol Peripheral nerves Peripheral neuropathy Pharmaceutical sciences Regeneration Spinal cord Tumor necrosis factor-α
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